Constitutive TNF-α signaling in neonates is essential for the development of tissue-resident leukocyte profiles at barrier sites.
Bickes MS, Pirr S, Heinemann AS, Fehlhaber B, Halle S, Völlger L, Willers M, Richter M, Böhne C, Albrecht M, Langer M, Pfeifer S, Jonigk D, Vieten G, Ure B, von Kaisenberg C, Förster R, von Köckritz-Blickwede M, Hansen G, Viemann D.
Bickes MS, et al. Among authors: albrecht m.
FASEB J. 2019 Oct;33(10):10633-10647. doi: 10.1096/fj.201900796R. Epub 2019 Jun 29.
FASEB J. 2019.
PMID: 31262195
Collectively, these data suggest that constitutive TNF-alpha-mediated sterile endothelial activation in newborn infants contributes to the increased risk of developing SIRS but is needed to ensure the postnatal recruitment of leukocytes to organs and interfaces.-Bickes, M. …
Collectively, these data suggest that constitutive TNF-alpha-mediated sterile endothelial activation in newborn infants contributes to the i …