Shin I - Search Results

1

A Pitcher-and-Catcher Mechanism Drives Endogenous Substrate Isomerization by a Dehydrogenase in Kynurenine Metabolism.

Yang Y, Davis I, Ha U, Wang Y, Shin I, Liu A. Yang Y, et al. Among authors: shin i. J Biol Chem. 2016 Dec 16;291(51):26252-26261. doi: 10.1074/jbc.M116.759712. Epub 2016 Nov 3. J Biol Chem. 2016. PMID: 27810899 Free PMC article.

2

Crystal structure of human cysteamine dioxygenase provides a structural rationale for its function as an oxygen sensor.

Wang Y, Shin I, Li J, Liu A. Wang Y, et al. Among authors: shin i. J Biol Chem. 2021 Oct;297(4):101176. doi: 10.1016/j.jbc.2021.101176. Epub 2021 Sep 8. J Biol Chem. 2021. PMID: 34508780 Free PMC article.

3

Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase.

Li J, Griffith WP, Davis I, Shin I, Wang J, Li F, Wang Y, Wherritt DJ, Liu A. Li J, et al. Among authors: shin i. Nat Chem Biol. 2018 Sep;14(9):853-860. doi: 10.1038/s41589-018-0085-5. Epub 2018 Jun 25. Nat Chem Biol. 2018. PMID: 29942080 Free PMC article.

4

Molecular Rationale for Partitioning between C-H and C-F Bond Activation in Heme-Dependent Tyrosine Hydroxylase.

Wang Y, Davis I, Shin I, Xu H, Liu A. Wang Y, et al. Among authors: shin i. J Am Chem Soc. 2021 Mar 31;143(12):4680-4693. doi: 10.1021/jacs.1c00175. Epub 2021 Mar 18. J Am Chem Soc. 2021. PMID: 33734681 Free PMC article.

5

A novel catalytic heme cofactor in SfmD with a single thioether bond and a bis-His ligand set revealed by a de novo crystal structural and spectroscopic study.

Shin I, Davis I, Nieves-Merced K, Wang Y, McHardy S, Liu A. Shin I, et al. Chem Sci. 2021 Jan 22;12(11):3984-3998. doi: 10.1039/d0sc06369j. Chem Sci. 2021. PMID: 34163669 Free PMC article.

6

A new regime of heme-dependent aromatic oxygenase superfamily.

Shin I, Wang Y, Liu A. Shin I, et al. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2106561118. doi: 10.1073/pnas.2106561118. Proc Natl Acad Sci U S A. 2021. PMID: 34667125 Free PMC article.

7

Crystal Structures of L-DOPA Dioxygenase from Streptomyces sclerotialus.

Wang Y, Shin I, Fu Y, Colabroy KL, Liu A. Wang Y, et al. Among authors: shin i. Biochemistry. 2019 Dec 31;58(52):5339-5350. doi: 10.1021/acs.biochem.9b00396. Epub 2019 Jun 25. Biochemistry. 2019. PMID: 31180203 Free PMC article.

8

Biocatalytic Carbon-Hydrogen and Carbon-Fluorine Bond Cleavage through Hydroxylation Promoted by a Histidyl-Ligated Heme Enzyme.

Wang Y, Davis I, Shin I, Wherritt DJ, Griffith WP, Dornevil K, Colabroy KL, Liu A. Wang Y, et al. Among authors: shin i. ACS Catal. 2019 Jun 7;9(6):4764-4776. doi: 10.1021/acscatal.9b00231. Epub 2019 Apr 11. ACS Catal. 2019. PMID: 31355048 Free PMC article.

9

Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency.

Ferreira P, Shin I, Sosova I, Dornevil K, Jain S, Dewey D, Liu F, Liu A. Ferreira P, et al. Among authors: shin i. Mol Genet Metab. 2017 Apr;120(4):317-324. doi: 10.1016/j.ymgme.2017.02.009. Epub 2017 Mar 1. Mol Genet Metab. 2017. PMID: 28285122 Free PMC article.

10

Stepwise O-Atom Transfer in Heme-Based Tryptophan Dioxygenase: Role of Substrate Ammonium in Epoxide Ring Opening.

Shin I, Ambler BR, Wherritt D, Griffith WP, Maldonado AC, Altman RA, Liu A. Shin I, et al. J Am Chem Soc. 2018 Mar 28;140(12):4372-4379. doi: 10.1021/jacs.8b00262. Epub 2018 Mar 15. J Am Chem Soc. 2018. PMID: 29506384 Free PMC article.

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