Okun I - Search Results

1

An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis.

Svensson KA, Heinz BA, Schaus JM, Beck JP, Hao J, Krushinski JH, Reinhard MR, Cohen MP, Hellman SL, Getman BG, Wang X, Menezes MM, Maren DL, Falcone JF, Anderson WH, Wright RA, Morin SM, Knopp KL, Adams BL, Rogovoy B, Okun I, Suter TM, Statnick MA, Gehlert DR, Nelson DL, Lucaites VL, Emkey R, DeLapp NW, Wiernicki TR, Cramer JW, Yang CR, Bruns RF. Svensson KA, et al. Among authors: okun i. J Pharmacol Exp Ther. 2017 Jan;360(1):117-128. doi: 10.1124/jpet.116.236372. Epub 2016 Nov 3. J Pharmacol Exp Ther. 2017. PMID: 27811173 Free PMC article.

2

2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: new series of highly potent and specific serotonin 5-HT6 receptor antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Koryakova AG, Mitkin OD, Tkachenko SE, Kysil VM, Okun I. Ivachtchenko AV, et al. Among authors: okun i. Eur J Med Chem. 2011 Apr;46(4):1189-97. doi: 10.1016/j.ejmech.2011.01.038. Epub 2011 Feb 1. Eur J Med Chem. 2011. PMID: 21333408

3

Solution phase parallel synthesis of substituted 3-phenylsulfonyl-[1,2,3]triazolo[1,5-a]quinazolines: selective serotonin 5-HT(6) receptor antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Koryakova AG, Kovalenko SM, Mitkin OD, Okun IM, Ravnyeyko IM, Tkachenko SE, Zaremba OV. Ivachtchenko AV, et al. J Comb Chem. 2010 Jul 12;12(4):445-52. doi: 10.1021/cc1000049. J Comb Chem. 2010. PMID: 20349953

4

Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.

Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Tkachenko SE, Okun IM. Ivachtchenko AV, et al. Among authors: okun im. J Med Chem. 2011 Dec 8;54(23):8161-73. doi: 10.1021/jm201079g. Epub 2011 Nov 10. J Med Chem. 2011. PMID: 22029285

5

Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity.

Marjanovic J, Chalupska D, Patenode C, Coster A, Arnold E, Ye A, Anesi G, Lu Y, Okun I, Tkachenko S, Haselkorn R, Gornicki P. Marjanovic J, et al. Among authors: okun i. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9093-8. doi: 10.1073/pnas.1003721107. Epub 2010 May 3. Proc Natl Acad Sci U S A. 2010. PMID: 20439761 Free PMC article.

6

Discovery of TBC11251, a potent, long acting, orally active endothelin receptor-A selective antagonist.

Wu C, Chan MF, Stavros F, Raju B, Okun I, Mong S, Keller KM, Brock T, Kogan TP, Dixon RA. Wu C, et al. Among authors: okun i. J Med Chem. 1997 May 23;40(11):1690-7. doi: 10.1021/jm9700068. J Med Chem. 1997. PMID: 9171878

7

Synthesis and structure-activity relationship of 4-substituted 2-(2-acetyloxyethyl)-8-(morpholine-4-sulfonyl)pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors.

Kravchenko DV, Kuzovkova YA, Kysil VM, Tkachenko SE, Maliarchouk S, Okun IM, Balakin KV, Ivachtchenko AV. Kravchenko DV, et al. J Med Chem. 2005 Jun 2;48(11):3680-3. doi: 10.1021/jm048987t. J Med Chem. 2005. PMID: 15916416

8

Pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. Synthesis and SAR of 2-substituted 4-methyl-8-(morpholine-4-sulfonyl)-pyrrolo[3,4-c]quinoline-1,3-diones.

Kravchenko DV, Kysil VM, Tkachenko SE, Maliarchouk S, Okun IM, Ivachtchenko AV. Kravchenko DV, et al. Eur J Med Chem. 2005 Dec;40(12):1377-83. doi: 10.1016/j.ejmech.2005.07.011. Epub 2005 Sep 15. Eur J Med Chem. 2005. PMID: 16169127

9

Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists.

Ivachtchenko AV, Frolov EB, Mitkin OD, Kysil VM, Khvat AV, Okun IM, Tkachenko SE. Ivachtchenko AV, et al. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3183-7. doi: 10.1016/j.bmcl.2009.04.128. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19443217

10

8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.

Ivachtchenko AV, Mitkin OD, Tkachenko SE, Okun IM, Kysil VM. Ivachtchenko AV, et al. Eur J Med Chem. 2010 Feb;45(2):782-9. doi: 10.1016/j.ejmech.2009.10.035. Epub 2009 Oct 31. Eur J Med Chem. 2010. PMID: 19939513

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