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Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity.
Carmi Y, Prestwood TR, Spitzer MH, Linde IL, Chabon J, Reticker-Flynn NE, Bhattacharya N, Zhang H, Zhang X, Basto PA, Burt BM, Alonso MN, Engleman EG. Carmi Y, et al. Among authors: engleman eg. JCI Insight. 2016 Nov 3;1(18):e89020. doi: 10.1172/jci.insight.89020. JCI Insight. 2016. PMID: 27812544 Free PMC article.
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies.
Winer DA, Winer S, Shen L, Wadia PP, Yantha J, Paltser G, Tsui H, Wu P, Davidson MG, Alonso MN, Leong HX, Glassford A, Caimol M, Kenkel JA, Tedder TF, McLaughlin T, Miklos DB, Dosch HM, Engleman EG. Winer DA, et al. Among authors: engleman eg. Nat Med. 2011 May;17(5):610-7. doi: 10.1038/nm.2353. Epub 2011 Apr 17. Nat Med. 2011. PMID: 21499269 Free PMC article.
Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.
Junttila IS, Creusot RJ, Moraga I, Bates DL, Wong MT, Alonso MN, Suhoski MM, Lupardus P, Meier-Schellersheim M, Engleman EG, Utz PJ, Fathman CG, Paul WE, Garcia KC. Junttila IS, et al. Among authors: engleman eg. Nat Chem Biol. 2012 Dec;8(12):990-8. doi: 10.1038/nchembio.1096. Epub 2012 Oct 28. Nat Chem Biol. 2012. PMID: 23103943 Free PMC article.
Th17 cells induce Th1-polarizing monocyte-derived dendritic cells.
Davidson MG, Alonso MN, Yuan R, Axtell RC, Kenkel JA, Suhoski MM, González JC, Steinman L, Engleman EG. Davidson MG, et al. Among authors: engleman eg. J Immunol. 2013 Aug 1;191(3):1175-87. doi: 10.4049/jimmunol.1203201. Epub 2013 Jun 21. J Immunol. 2013. PMID: 23794631 Free PMC article.
B-1a lymphocytes attenuate insulin resistance.
Shen L, Chng MH, Alonso MN, Yuan R, Winer DA, Engleman EG. Shen L, et al. Among authors: engleman eg. Diabetes. 2015 Feb;64(2):593-603. doi: 10.2337/db14-0554. Epub 2014 Sep 23. Diabetes. 2015. PMID: 25249575 Free PMC article.
312 results