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Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice.
Brachs S, Winkel AF, Tang H, Birkenfeld AL, Brunner B, Jahn-Hofmann K, Margerie D, Ruetten H, Schmoll D, Spranger J. Brachs S, et al. Among authors: birkenfeld al. Mol Metab. 2016 Aug 13;5(11):1072-1082. doi: 10.1016/j.molmet.2016.08.004. eCollection 2016 Nov. Mol Metab. 2016. PMID: 27818933 Free PMC article.
Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice.
Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, König J, Lieske S, Carmean CM, Frederick DW, Weismann D, Knauf F, Irusta PM, De Cabo R, Helfand SL, Samuel VT, Shulman GI. Birkenfeld AL, et al. Cell Metab. 2011 Aug 3;14(2):184-95. doi: 10.1016/j.cmet.2011.06.009. Cell Metab. 2011. PMID: 21803289 Free PMC article.
The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes.
Neuschäfer-Rube F, Lieske S, Kuna M, Henkel J, Perry RJ, Erion DM, Pesta D, Willmes DM, Brachs S, von Loeffelholz C, Tolkachov A, Schupp M, Pathe-Neuschäfer-Rube A, Pfeiffer AF, Shulman GI, Püschel GP, Birkenfeld AL. Neuschäfer-Rube F, et al. Among authors: birkenfeld al. Diabetes. 2014 Mar;63(3):1048-57. doi: 10.2337/db13-0749. Epub 2013 Nov 12. Diabetes. 2014. PMID: 24222346 Free PMC article.
Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice.
Krüger J, Brachs S, Trappiel M, Kintscher U, Meyborg H, Wellnhofer E, Thöne-Reineke C, Stawowy P, Östman A, Birkenfeld AL, Böhmer FD, Kappert K. Krüger J, et al. Among authors: birkenfeld al. Mol Metab. 2015 Feb 12;4(4):325-36. doi: 10.1016/j.molmet.2015.02.001. eCollection 2015 Apr. Mol Metab. 2015. PMID: 25830095 Free PMC article.
Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5).
Pesta DH, Perry RJ, Guebre-Egziabher F, Zhang D, Jurczak M, Fischer-Rosinsky A, Daniels MA, Willmes DM, Bhanot S, Bornstein SR, Knauf F, Samuel VT, Shulman GI, Birkenfeld AL. Pesta DH, et al. Among authors: birkenfeld al. Aging (Albany NY). 2015 Dec;7(12):1086-93. doi: 10.18632/aging.100854. Aging (Albany NY). 2015. PMID: 26647160 Free PMC article.
298 results