Georgiou G - Search Results

1

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination.

Lee J, Boutz DR, Chromikova V, Joyce MG, Vollmers C, Leung K, Horton AP, DeKosky BJ, Lee CH, Lavinder JJ, Murrin EM, Chrysostomou C, Hoi KH, Tsybovsky Y, Thomas PV, Druz A, Zhang B, Zhang Y, Wang L, Kong WP, Park D, Popova LI, Dekker CL, Davis MM, Carter CE, Ross TM, Ellington AD, Wilson PC, Marcotte EM, Mascola JR, Ippolito GC, Krammer F, Quake SR, Kwong PD, Georgiou G. Lee J, et al. Among authors: georgiou g. Nat Med. 2016 Dec;22(12):1456-1464. doi: 10.1038/nm.4224. Epub 2016 Nov 7. Nat Med. 2016. PMID: 27820605 Free PMC article.

2

Automated selection of aptamers against protein targets translated in vitro: from gene to aptamer.

Cox JC, Hayhurst A, Hesselberth J, Bayer TS, Georgiou G, Ellington AD. Cox JC, et al. Among authors: georgiou g. Nucleic Acids Res. 2002 Oct 15;30(20):e108. doi: 10.1093/nar/gnf107. Nucleic Acids Res. 2002. PMID: 12384610 Free PMC article.

3

Engineering antibody fragments to fold in the absence of disulfide bonds.

Seo MJ, Jeong KJ, Leysath CE, Ellington AD, Iverson BL, Georgiou G. Seo MJ, et al. Among authors: georgiou g. Protein Sci. 2009 Feb;18(2):259-67. doi: 10.1002/pro.31. Protein Sci. 2009. PMID: 19177559 Free PMC article.

4

Rapid construction and characterization of synthetic antibody libraries without DNA amplification.

Ge X, Mazor Y, Hunicke-Smith SP, Ellington AD, Georgiou G. Ge X, et al. Among authors: georgiou g. Biotechnol Bioeng. 2010 Jun 15;106(3):347-57. doi: 10.1002/bit.22712. Biotechnol Bioeng. 2010. PMID: 20198660

5

Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells.

Reddy ST, Ge X, Miklos AE, Hughes RA, Kang SH, Hoi KH, Chrysostomou C, Hunicke-Smith SP, Iverson BL, Tucker PW, Ellington AD, Georgiou G. Reddy ST, et al. Among authors: georgiou g. Nat Biotechnol. 2010 Sep;28(9):965-9. doi: 10.1038/nbt.1673. Epub 2010 Aug 29. Nat Biotechnol. 2010. PMID: 20802495

6

Structure-based design of supercharged, highly thermoresistant antibodies.

Miklos AE, Kluwe C, Der BS, Pai S, Sircar A, Hughes RA, Berrondo M, Xu J, Codrea V, Buckley PE, Calm AM, Welsh HS, Warner CR, Zacharko MA, Carney JP, Gray JJ, Georgiou G, Kuhlman B, Ellington AD. Miklos AE, et al. Among authors: georgiou g. Chem Biol. 2012 Apr 20;19(4):449-55. doi: 10.1016/j.chembiol.2012.01.018. Chem Biol. 2012. PMID: 22520751 Free PMC article.

7

Antibody repertoires in humanized NOD-scid-IL2Rγ(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse.

Ippolito GC, Hoi KH, Reddy ST, Carroll SM, Ge X, Rogosch T, Zemlin M, Shultz LD, Ellington AD, Vandenberg CL, Georgiou G. Ippolito GC, et al. Among authors: georgiou g. PLoS One. 2012;7(4):e35497. doi: 10.1371/journal.pone.0035497. Epub 2012 Apr 27. PLoS One. 2012. PMID: 22558161 Free PMC article.

8

SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis.

Romero PA, Stone E, Lamb C, Chantranupong L, Krause A, Miklos AE, Hughes RA, Fechtel B, Ellington AD, Arnold FH, Georgiou G. Romero PA, et al. Among authors: georgiou g. ACS Synth Biol. 2012 Jun 15;1(6):221-8. doi: 10.1021/sb300014t. ACS Synth Biol. 2012. PMID: 22737599 Free PMC article.

9

High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire.

DeKosky BJ, Ippolito GC, Deschner RP, Lavinder JJ, Wine Y, Rawlings BM, Varadarajan N, Giesecke C, Dörner T, Andrews SF, Wilson PC, Hunicke-Smith SP, Willson CG, Ellington AD, Georgiou G. DeKosky BJ, et al. Among authors: georgiou g. Nat Biotechnol. 2013 Feb;31(2):166-9. doi: 10.1038/nbt.2492. Epub 2013 Jan 20. Nat Biotechnol. 2013. PMID: 23334449 Free PMC article.

10

Molecular deconvolution of the monoclonal antibodies that comprise the polyclonal serum response.

Wine Y, Boutz DR, Lavinder JJ, Miklos AE, Hughes RA, Hoi KH, Jung ST, Horton AP, Murrin EM, Ellington AD, Marcotte EM, Georgiou G. Wine Y, et al. Among authors: georgiou g. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2993-8. doi: 10.1073/pnas.1213737110. Epub 2013 Feb 4. Proc Natl Acad Sci U S A. 2013. PMID: 23382245 Free PMC article.

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