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Page 1
Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.
Blanco G, Puiggros A, Baliakas P, Athanasiadou A, García-Malo M, Collado R, Xochelli A, Rodríguez-Rivera M, Ortega M, Calasanz MJ, Luño E, Vargas M, Grau J, Martínez-Laperche C, Valiente A, Cervera J, Anagnostopoulos A, Gimeno E, Abella E, Stalika E, Hernández-Rivas JM, Ortuño FJ, Robles D, Ferrer A, Ivars D, González M, Bosch F, Abrisqueta P, Stamatopoulos K, Espinet B. Blanco G, et al. Among authors: ortuno fj. Oncotarget. 2016 Dec 6;7(49):80916-80924. doi: 10.18632/oncotarget.13106. Oncotarget. 2016. PMID: 27821812 Free PMC article.
Genetic abnormalities and clinical outcome in chronic lymphocytic leukemia.
Ripollés L, Ortega M, Ortuño F, González A, Losada J, Ojanguren J, Soler JA, Bergua J, Coll MD, Caballín MR. Ripollés L, et al. Cancer Genet Cytogenet. 2006 Nov;171(1):57-64. doi: 10.1016/j.cancergencyto.2006.07.006. Cancer Genet Cytogenet. 2006. PMID: 17074592
A high number of losses in 13q14 chromosome band is associated with a worse outcome and biological differences in patients with B-cell chronic lymphoid leukemia.
Hernández JA, Rodríguez AE, González M, Benito R, Fontanillo C, Sandoval V, Romero M, Martín-Núñez G, de Coca AG, Fisac R, Galende J, Recio I, Ortuño F, García JL, de las Rivas J, Gutiérrez NC, San Miguel JF, Hernández JM. Hernández JA, et al. Haematologica. 2009 Mar;94(3):364-71. doi: 10.3324/haematol.13862. Haematologica. 2009. PMID: 19252174 Free PMC article.
Interstitial 13q14 deletions detected in the karyotype and translocations with concomitant deletion at 13q14 in chronic lymphocytic leukemia: different genetic mechanisms but equivalent poorer clinical outcome.
Puiggros A, Venturas M, Salido M, Blanco G, Fernandez-Rodriguez C, Collado R, Valiente A, Ruiz-Xivillé N, Carrió A, Ortuño FJ, Luño E, Calasanz MJ, Ardanaz MT, Piñán MÁ, Talavera E, González MT, Ortega M, Marugán I, Ferrer A, Gimeno E, Bellosillo B, Delgado J, Hernández JÁ, Hernández-Rivas JM, Espinet B; Grupo Cooperativo Español de Citogenética Hematológica (GCECGH); Grupo Español de Leucemia Linfática Crónica (GELLC). Puiggros A, et al. Among authors: ortuno fj. Genes Chromosomes Cancer. 2014 Sep;53(9):788-97. doi: 10.1002/gcc.22188. Epub 2014 Jun 10. Genes Chromosomes Cancer. 2014. PMID: 24915757
Prognostic signature and clonality pattern of recurrently mutated genes in inactive chronic lymphocytic leukemia.
Hurtado AM, Chen-Liang TH, Przychodzen B, Hamedi C, Muñoz-Ballester J, Dienes B, García-Malo MD, Antón AI, de Arriba F, Teruel-Montoya R, Ortuño FJ, Vicente V, Maciejewski JP, Jerez A. Hurtado AM, et al. Among authors: ortuno fj. Blood Cancer J. 2015 Aug 28;5(8):e342. doi: 10.1038/bcj.2015.65. Blood Cancer J. 2015. PMID: 26314984 Free PMC article.
Monosomal karyotype in chronic lymphocytic leukemia: Association with clinical and biological features and potential prognostic significance.
Baptista MJ, Granada I, Morgades M, Calasanz MJ, Canals J, Robles De Castro D, Luño E, Ruiz-Xivillé N, Rodríguez-Hernández I, González T, Terol MJ, Valiente A, Ortuño F, Garcia-Malo MD, Piñan MÁ, Oliveira AC, Talavera M, Buño I, Batlle-López A, Moreno C, Ferra C, Solé F. Baptista MJ, et al. Am J Hematol. 2017 Jul;92(7):E132-E135. doi: 10.1002/ajh.24754. Epub 2017 Jun 1. Am J Hematol. 2017. PMID: 28383114 Free article. Clinical Trial. No abstract available.
Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions.
Puiggros A, Collado R, Calasanz MJ, Ortega M, Ruiz-Xivillé N, Rivas-Delgado A, Luño E, González T, Navarro B, García-Malo M, Valiente A, Hernández JÁ, Ardanaz MT, Piñan MÁ, Blanco ML, Hernández-Sánchez M, Batlle-López A, Salgado R, Salido M, Ferrer A, Abrisqueta P, Gimeno E, Abella E, Ferrá C, Terol MJ, Ortuño F, Costa D, Moreno C, Carbonell F, Bosch F, Delgado J, Espinet B. Puiggros A, et al. Oncotarget. 2017 Apr 21;8(33):54297-54303. doi: 10.18632/oncotarget.17350. eCollection 2017 Aug 15. Oncotarget. 2017. PMID: 28903342 Free PMC article.
An increased percentage of myeloid CD34+ bone marrow cells stratifies intermediate IPSS-R myelodysplastic syndrome patients into prognostically significant groups.
Chen-Liang TH, Casado-Prieto AM, Campos-Rodríguez V, Hurtado AM, Amigo ML, García-Malo MD, Vicente V, Ortuño FJ, Jerez A. Chen-Liang TH, et al. Among authors: ortuno fj. Int J Lab Hematol. 2018 Oct;40(5):549-555. doi: 10.1111/ijlh.12860. Epub 2018 May 18. Int J Lab Hematol. 2018. PMID: 29774987
NOTCH1 mutation in chronic lymphocytic leukaemia is associated with an enhanced cell cycle G1/S transition and specific cyclin overexpression: Preclinical ground for targeted inhibition.
Carrillo-Tornel S, Chen-Liang TH, Zurdo M, Puiggros A, Gómez-Llonín A, García-Malo MD, Cuenca-Zamora EJ, Ortuño FJ, López AMH, Espinet B, Jerez A. Carrillo-Tornel S, et al. Among authors: ortuno fj. Br J Haematol. 2023 May;201(3):470-479. doi: 10.1111/bjh.18609. Epub 2022 Dec 27. Br J Haematol. 2023. PMID: 36573331
77 results