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T follicular helper cells restricted by IRF8 contribute to T cell-mediated inflammation.
Zhang R, Qi CF, Hu Y, Shan Y, Hsieh YP, Xu F, Lu G, Dai J, Gupta M, Cui M, Peng L, Yang J, Xue Q, Chen-Liang R, Chen K, Zhang Y, Fung-Leung WP, Mora JR, Li L, Morse HC 3rd, Ozato K, Heeger PS, Xiong H. Zhang R, et al. Among authors: peng l. J Autoimmun. 2019 Jan;96:113-122. doi: 10.1016/j.jaut.2018.09.001. Epub 2018 Sep 19. J Autoimmun. 2019. PMID: 30241692 Free PMC article.
5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation.
Wang J, Peng L, Zhang R, Zheng Z, Chen C, Cheung KL, Cui M, Bian G, Xu F, Chiang D, Hu Y, Chen Y, Lu G, Yang J, Zhang H, Yang J, Zhu H, Chen SH, Liu K, Zhou MM, Sikora AG, Li L, Jiang B, Xiong H. Wang J, et al. Among authors: peng l. Oncotarget. 2016 Apr 12;7(15):19312-26. doi: 10.18632/oncotarget.8344. Oncotarget. 2016. PMID: 27027355 Free PMC article.
T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation.
Jianjun Yang, Zhang R, Lu G, Shen Y, Peng L, Zhu C, Cui M, Wang W, Arnaboldi P, Tang M, Gupta M, Qi CF, Jayaraman P, Zhu H, Jiang B, Chen SH, He JC, Ting AT, Zhou MM, Kuchroo VK, Morse HC 3rd, Ozato K, Sikora AG, Xiong H. Jianjun Yang, et al. Among authors: peng l. J Exp Med. 2013 Jul 1;210(7):1447-62. doi: 10.1084/jem.20122494. J Exp Med. 2013. PMID: 23797094 Free PMC article.
BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Cheung K, Lu G, Sharma R, Vincek A, Zhang R, Plotnikov AN, Zhang F, Zhang Q, Ju Y, Hu Y, Zhao L, Han X, Meslamani J, Xu F, Jaganathan A, Shen T, Zhu H, Rusinova E, Zeng L, Zhou J, Yang J, Peng L, Ohlmeyer M, Walsh MJ, Zhang DY, Xiong H, Zhou MM. Cheung K, et al. Among authors: peng l. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2952-2957. doi: 10.1073/pnas.1615601114. Epub 2017 Mar 6. Proc Natl Acad Sci U S A. 2017. PMID: 28265070 Free PMC article.
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