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Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.
Gabryszewski SJ, Dhingra SK, Combrinck JM, Lewis IA, Callaghan PS, Hassett MR, Siriwardana A, Henrich PP, Lee AH, Gnädig NF, Musset L, Llinás M, Egan TJ, Roepe PD, Fidock DA. Gabryszewski SJ, et al. Among authors: egan tj. PLoS Pathog. 2016 Nov 10;12(11):e1005976. doi: 10.1371/journal.ppat.1005976. eCollection 2016 Nov. PLoS Pathog. 2016. PMID: 27832198 Free PMC article.
Fate of haem iron in the malaria parasite Plasmodium falciparum.
Egan TJ, Combrinck JM, Egan J, Hearne GR, Marques HM, Ntenteni S, Sewell BT, Smith PJ, Taylor D, van Schalkwyk DA, Walden JC. Egan TJ, et al. Among authors: egan j. Biochem J. 2002 Jul 15;365(Pt 2):343-7. doi: 10.1042/BJ20020793. Biochem J. 2002. PMID: 12033986 Free PMC article.
Strategies to reverse drug resistance in malaria.
Egan TJ, Kaschula CH. Egan TJ, et al. Curr Opin Infect Dis. 2007 Dec;20(6):598-604. doi: 10.1097/QCO.0b013e3282f1673a. Curr Opin Infect Dis. 2007. PMID: 17975410 Review.
Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).
Zishiri VK, Joshi MC, Hunter R, Chibale K, Smith PJ, Summers RL, Martin RE, Egan TJ. Zishiri VK, et al. Among authors: egan tj. J Med Chem. 2011 Oct 13;54(19):6956-68. doi: 10.1021/jm2009698. Epub 2011 Sep 13. J Med Chem. 2011. PMID: 21875063
Insights into the role of heme in the mechanism of action of antimalarials.
Combrinck JM, Mabotha TE, Ncokazi KK, Ambele MA, Taylor D, Smith PJ, Hoppe HC, Egan TJ. Combrinck JM, et al. Among authors: egan tj. ACS Chem Biol. 2013 Jan 18;8(1):133-7. doi: 10.1021/cb300454t. Epub 2012 Oct 11. ACS Chem Biol. 2013. PMID: 23043646 Free PMC article.
172 results