Fidock DA - Search Results

1

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.

Gabryszewski SJ, Dhingra SK, Combrinck JM, Lewis IA, Callaghan PS, Hassett MR, Siriwardana A, Henrich PP, Lee AH, Gnädig NF, Musset L, Llinás M, Egan TJ, Roepe PD, Fidock DA. Gabryszewski SJ, et al. Among authors: fidock da. PLoS Pathog. 2016 Nov 10;12(11):e1005976. doi: 10.1371/journal.ppat.1005976. eCollection 2016 Nov. PLoS Pathog. 2016. PMID: 27832198 Free PMC article.

2

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.

Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LM, Sidhu AB, Naudé B, Deitsch KW, Su XZ, Wootton JC, Roepe PD, Wellems TE. Fidock DA, et al. Mol Cell. 2000 Oct;6(4):861-71. doi: 10.1016/s1097-2765(05)00077-8. Mol Cell. 2000. PMID: 11090624 Free PMC article.

3

Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America.

Mehlotra RK, Fujioka H, Roepe PD, Janneh O, Ursos LM, Jacobs-Lorena V, McNamara DT, Bockarie MJ, Kazura JW, Kyle DE, Fidock DA, Zimmerman PA. Mehlotra RK, et al. Among authors: fidock da. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12689-94. doi: 10.1073/pnas.221440898. Proc Natl Acad Sci U S A. 2001. PMID: 11675500 Free PMC article.

4

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.

Cooper RA, Ferdig MT, Su XZ, Ursos LM, Mu J, Nomura T, Fujioka H, Fidock DA, Roepe PD, Wellems TE. Cooper RA, et al. Among authors: fidock da. Mol Pharmacol. 2002 Jan;61(1):35-42. doi: 10.1124/mol.61.1.35. Mol Pharmacol. 2002. PMID: 11752204

5

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.

Sidhu AB, Verdier-Pinard D, Fidock DA. Sidhu AB, et al. Among authors: fidock da. Science. 2002 Oct 4;298(5591):210-3. doi: 10.1126/science.1074045. Science. 2002. PMID: 12364805 Free PMC article.

6

Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter.

Waller KL, Muhle RA, Ursos LM, Horrocks P, Verdier-Pinard D, Sidhu AB, Fujioka H, Roepe PD, Fidock DA. Waller KL, et al. Among authors: fidock da. J Biol Chem. 2003 Aug 29;278(35):33593-601. doi: 10.1074/jbc.M302215200. Epub 2003 Jun 17. J Biol Chem. 2003. PMID: 12813054 Free article.

7

Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.

Bennett TN, Kosar AD, Ursos LM, Dzekunov S, Singh Sidhu AB, Fidock DA, Roepe PD. Bennett TN, et al. Among authors: fidock da. Mol Biochem Parasitol. 2004 Jan;133(1):99-114. doi: 10.1016/j.molbiopara.2003.09.008. Mol Biochem Parasitol. 2004. PMID: 14668017

8

Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents.

Johnson DJ, Fidock DA, Mungthin M, Lakshmanan V, Sidhu AB, Bray PG, Ward SA. Johnson DJ, et al. Among authors: fidock da. Mol Cell. 2004 Sep 24;15(6):867-77. doi: 10.1016/j.molcel.2004.09.012. Mol Cell. 2004. PMID: 15383277 Free PMC article.

9

A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.

Lakshmanan V, Bray PG, Verdier-Pinard D, Johnson DJ, Horrocks P, Muhle RA, Alakpa GE, Hughes RH, Ward SA, Krogstad DJ, Sidhu AB, Fidock DA. Lakshmanan V, et al. Among authors: fidock da. EMBO J. 2005 Jul 6;24(13):2294-305. doi: 10.1038/sj.emboj.7600681. Epub 2005 Jun 9. EMBO J. 2005. PMID: 15944738 Free PMC article.

10

Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms.

Reeves DC, Liebelt DA, Lakshmanan V, Roepe PD, Fidock DA, Akabas MH. Reeves DC, et al. Among authors: fidock da. Mol Biochem Parasitol. 2006 Dec;150(2):288-99. doi: 10.1016/j.molbiopara.2006.09.001. Epub 2006 Sep 25. Mol Biochem Parasitol. 2006. PMID: 17014918 Free PMC article.

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