Gibbs JP - Search Results

1

Impact of Target-Mediated Elimination on the Dose and Regimen of Evolocumab, a Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9).

Gibbs JP, Doshi S, Kuchimanchi M, Grover A, Emery MG, Dodds MG, Gibbs MA, Somaratne R, Wasserman SM, Blom D. Gibbs JP, et al. Among authors: gibbs ma. J Clin Pharmacol. 2017 May;57(5):616-626. doi: 10.1002/jcph.840. Epub 2016 Nov 15. J Clin Pharmacol. 2017. PMID: 27861991 Free PMC article. Clinical Trial.

2

A model-based meta-analysis of monoclonal antibody pharmacokinetics to guide optimal first-in-human study design.

Davda JP, Dodds MG, Gibbs MA, Wisdom W, Gibbs J. Davda JP, et al. Among authors: gibbs j, gibbs ma. MAbs. 2014 Jul-Aug;6(4):1094-102. doi: 10.4161/mabs.29095. Epub 2014 May 16. MAbs. 2014. PMID: 24837591 Free PMC article.

3

Association Between Circulating Baseline Proprotein Convertase Subtilisin Kexin Type 9 Levels and Efficacy of Evolocumab.

Desai NR, Giugliano RP, Wasserman SM, Gibbs JP, Liu T, Scott R, Sabatine MS. Desai NR, et al. Among authors: gibbs jp. JAMA Cardiol. 2017 May 1;2(5):556-560. doi: 10.1001/jamacardio.2016.5395. JAMA Cardiol. 2017. PMID: 28122070 Free PMC article.

4

Clinical Pharmacokinetics and Pharmacodynamics of Evolocumab, a PCSK9 Inhibitor.

Kasichayanula S, Grover A, Emery MG, Gibbs MA, Somaratne R, Wasserman SM, Gibbs JP. Kasichayanula S, et al. Among authors: gibbs jp, gibbs ma. Clin Pharmacokinet. 2018 Jul;57(7):769-779. doi: 10.1007/s40262-017-0620-7. Clin Pharmacokinet. 2018. PMID: 29353350 Free PMC article. Review.

5

Population pharmacokinetics and exposure-response modeling and simulation for evolocumab in healthy volunteers and patients with hypercholesterolemia.

Kuchimanchi M, Grover A, Emery MG, Somaratne R, Wasserman SM, Gibbs JP, Doshi S. Kuchimanchi M, et al. Among authors: gibbs jp. J Pharmacokinet Pharmacodyn. 2018 Jun;45(3):505-522. doi: 10.1007/s10928-018-9592-y. Epub 2018 May 7. J Pharmacokinet Pharmacodyn. 2018. PMID: 29736889 Free PMC article.

6

Comparison of LDL-C Reduction Using Different Evolocumab Doses and Intervals: Biological Insights and Treatment Implications.

Wasserman SM, Sabatine MS, Koren MJ, Giugliano RP, Legg JC, Emery MG, Doshi S, Liu T, Somaratne R, Gibbs JP. Wasserman SM, et al. Among authors: gibbs jp. J Cardiovasc Pharmacol Ther. 2018 Sep;23(5):423-432. doi: 10.1177/1074248418774043. Epub 2018 May 16. J Cardiovasc Pharmacol Ther. 2018. PMID: 29768954

7

Influence of Renal Function on Evolocumab Exposure, Pharmacodynamics, and Safety.

Lee E, Gibbs JP, Emery MG, Block G, Wasserman SM, Hamilton L, Kasichayanula S, Hanafin P, Somaratne R, Egbuna O. Lee E, et al. Among authors: gibbs jp. Clin Pharmacol Drug Dev. 2019 Apr;8(3):281-289. doi: 10.1002/cpdd.650. Epub 2019 Jan 24. Clin Pharmacol Drug Dev. 2019. PMID: 30676701 Free PMC article.

8

Evaluation of Evolocumab (AMG 145), a Fully Human Anti-PCSK9 IgG2 Monoclonal Antibody, in Subjects With Hepatic Impairment.

Gibbs JP, Slatter JG, Egbuna O, Geller M, Hamilton L, Dias CS, Xu RY, Johnson J, Wasserman SM, Emery MG. Gibbs JP, et al. J Clin Pharmacol. 2017 Apr;57(4):513-523. doi: 10.1002/jcph.832. Epub 2016 Oct 26. J Clin Pharmacol. 2017. PMID: 27667740 Free PMC article.

9

Pharmacokinetics, Immunogenicity, and Efficacy of Etanercept in Pediatric Patients With Moderate to Severe Plaque Psoriasis.

Langley RG, Kasichayanula S, Trivedi M, Aras GA, Kaliyaperumal A, Yuraszeck T, Gibbs J, Gibbs M, Kricorian G, Paller AS. Langley RG, et al. J Clin Pharmacol. 2018 Mar;58(3):340-346. doi: 10.1002/jcph.1029. Epub 2017 Nov 6. J Clin Pharmacol. 2018. PMID: 29106714 Clinical Trial.

10

Quantitative prediction of human pharmacokinetics for monoclonal antibodies: retrospective analysis of monkey as a single species for first-in-human prediction.

Dong JQ, Salinger DH, Endres CJ, Gibbs JP, Hsu CP, Stouch BJ, Hurh E, Gibbs MA. Dong JQ, et al. Among authors: gibbs jp, gibbs ma. Clin Pharmacokinet. 2011 Feb;50(2):131-42. doi: 10.2165/11537430-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21241072

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