Merkul E - Search Results

1

A Novel Platinum(II)-Based Bifunctional ADC Linker Benchmarked Using 89Zr-Desferal and Auristatin F-Conjugated Trastuzumab.

Sijbrandi NJ, Merkul E, Muns JA, Waalboer DC, Adamzek K, Bolijn M, Montserrat V, Somsen GW, Haselberg R, Steverink PJ, Houthoff HJ, van Dongen GA. Sijbrandi NJ, et al. Among authors: merkul e. Cancer Res. 2017 Jan 15;77(2):257-267. doi: 10.1158/0008-5472.CAN-16-1900. Epub 2016 Nov 21. Cancer Res. 2017. PMID: 27872093

2

In Vivo Characterization of Platinum(II)-Based Linker Technology for the Development of Antibody-Drug Conjugates: Taking Advantage of Dual Labeling with ^195mPt and ⁸⁹Zr.

Muns JA, Montserrat V, Houthoff HJ, Codée-van der Schilden K, Zwaagstra O, Sijbrandi NJ, Merkul E, van Dongen GAMS. Muns JA, et al. Among authors: merkul e. J Nucl Med. 2018 Jul;59(7):1146-1151. doi: 10.2967/jnumed.117.206672. Epub 2018 Mar 1. J Nucl Med. 2018. PMID: 29496986 Free article.

3

First platinum(II)-based metal-organic linker technology (Lx®) for a plug-and-play development of antibody-drug conjugates (ADCs).

Merkul E, Sijbrandi NJ, Muns JA, Aydin I, Adamzek K, Houthoff HJ, Nijmeijer B, Van Dongen GAMS. Merkul E, et al. Expert Opin Drug Deliv. 2019 Aug;16(8):783-793. doi: 10.1080/17425247.2019.1645118. Epub 2019 Jul 24. Expert Opin Drug Deliv. 2019. PMID: 31327255 Free article.

4

An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the Pt^II Linker Lx for Improved Manufacturability of Antibody-Drug Conjugates.

Merkul E, Muns JA, Sijbrandi NJ, Houthoff HJ, Nijmeijer B, van Rheenen G, Reedijk J, van Dongen GAMS. Merkul E, et al. Angew Chem Int Ed Engl. 2021 Feb 8;60(6):3008-3015. doi: 10.1002/anie.202011593. Epub 2021 Jan 15. Angew Chem Int Ed Engl. 2021. PMID: 33185916 Free PMC article.

5

Three-component synthesis of ynediones by a glyoxylation/Stephens-Castro coupling sequence.

Merkul E, Dohe J, Gers C, Rominger F, Müller TJ. Merkul E, et al. Angew Chem Int Ed Engl. 2011 Mar 21;50(13):2966-9. doi: 10.1002/anie.201007194. Epub 2011 Feb 23. Angew Chem Int Ed Engl. 2011. PMID: 21404378 No abstract available.

6

Catalytic syntheses of N-heterocyclic ynones and ynediones by in situ activation of carboxylic acids with oxalyl chloride.

Boersch C, Merkul E, Müller TJ. Boersch C, et al. Among authors: merkul e. Angew Chem Int Ed Engl. 2011 Oct 24;50(44):10448-52. doi: 10.1002/anie.201103296. Epub 2011 Sep 9. Angew Chem Int Ed Engl. 2011. PMID: 21910193 No abstract available.

7

Consecutive three-component synthesis of 3-(hetero)aryl-1H-pyrazoles with propynal diethylacetal as a three-carbon building block.

Levi L, Boersch C, Gers CF, Merkul E, Müller TJ. Levi L, et al. Among authors: merkul e. Molecules. 2011 Nov 7;16(11):9340-56. doi: 10.3390/molecules16119340. Molecules. 2011. PMID: 22064273 Free PMC article.

8

A novel one-pot three-component synthesis of 3-halofurans and sequential Suzuki coupling.

Karpov AS, Merkul E, Oeser T, Müller TJ. Karpov AS, et al. Among authors: merkul e. Chem Commun (Camb). 2005 May 28;(20):2581-3. doi: 10.1039/b502324f. Epub 2005 Apr 6. Chem Commun (Camb). 2005. PMID: 15900333

9

A new consecutive three-component oxazole synthesis by an amidation-coupling-cycloisomerization (ACCI) sequence.

Merkul E, Müller TJ. Merkul E, et al. Chem Commun (Camb). 2006 Dec 14;(46):4817-9. doi: 10.1039/b610839c. Chem Commun (Camb). 2006. PMID: 17345739

10

Consecutive three-component synthesis of ynones by decarbonylative Sonogashira coupling.

Merkul E, Oeser T, Müller TJ. Merkul E, et al. Chemistry. 2009;15(20):5006-11. doi: 10.1002/chem.200900119. Chemistry. 2009. PMID: 19360838

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