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Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.
Giubilaro J, Schuetz DA, Stepniewski TM, Namkung Y, Khoury E, Lara-Márquez M, Campbell S, Beautrait A, Armando S, Radresa O, Duchaine J, Lamarche-Vane N, Claing A, Selent J, Bouvier M, Marinier A, Laporte SA. Giubilaro J, et al. Among authors: duchaine j. Nat Commun. 2021 Aug 3;12(1):4688. doi: 10.1038/s41467-021-24968-y. Nat Commun. 2021. PMID: 34344896 Free PMC article.
GLI1-Inducible Glucuronidation Targets a Broad Spectrum of Drugs.
Zahreddine HA, Culjkovic-Kraljacic B, Gasiorek J, Duchaine J, Borden KLB. Zahreddine HA, et al. Among authors: duchaine j. ACS Chem Biol. 2019 Mar 15;14(3):348-355. doi: 10.1021/acschembio.8b01118. Epub 2019 Feb 19. ACS Chem Biol. 2019. PMID: 30763062
A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila.
Ashton-Beaucage D, Udell CM, Gendron P, Sahmi M, Lefrançois M, Baril C, Guenier AS, Duchaine J, Lamarre D, Lemieux S, Therrien M. Ashton-Beaucage D, et al. Among authors: duchaine j. PLoS Biol. 2014 Mar 18;12(3):e1001809. doi: 10.1371/journal.pbio.1001809. eCollection 2014 Mar. PLoS Biol. 2014. PMID: 24643257 Free PMC article.
Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses.
Baril M, Es-Saad S, Chatel-Chaix L, Fink K, Pham T, Raymond VA, Audette K, Guenier AS, Duchaine J, Servant M, Bilodeau M, Cohen E, Grandvaux N, Lamarre D. Baril M, et al. Among authors: duchaine j. PLoS Pathog. 2013;9(6):e1003416. doi: 10.1371/journal.ppat.1003416. Epub 2013 Jun 13. PLoS Pathog. 2013. PMID: 23785285 Free PMC article. Clinical Trial.
Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities.
Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laramée L, Gendron P, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, Haddad É, Landry JR, Ma J, Humphries RK, Roux PP, Hébert J, Gruber TA, Wilhelm BT, Cellot S. Cardin S, et al. Among authors: duchaine j. Blood Adv. 2019 Nov 12;3(21):3307-3321. doi: 10.1182/bloodadvances.2019030981. Blood Adv. 2019. PMID: 31698461 Free PMC article.
61 results