Zhang R - Search Results

1

Discovery of novel DNA methyltransferase 3A inhibitors via structure-based virtual screening and biological assays.

Shao Z, Xu P, Xu W, Li L, Liu S, Zhang R, Liu YC, Zhang C, Chen S, Luo C. Shao Z, et al. Among authors: zhang r, zhang c. Bioorg Med Chem Lett. 2017 Jan 15;27(2):342-346. doi: 10.1016/j.bmcl.2016.11.023. Epub 2016 Nov 11. Bioorg Med Chem Lett. 2017. PMID: 27899265

2

Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.

Ye F, Kong X, Zhang H, Liu Y, Shao Z, Jin J, Cai Y, Zhang R, Li L, Zhang YW, Liu YC, Zhang C, Xie W, Yu K, Ding H, Zhao K, Chen S, Jiang H, Baylin SB, Luo C. Ye F, et al. Among authors: zhang r, zhang c, zhang yw, zhang h. ACS Chem Biol. 2018 Mar 16;13(3):772-781. doi: 10.1021/acschembio.7b00890. Epub 2018 Feb 8. ACS Chem Biol. 2018. PMID: 29381856 Free PMC article.

3

Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening.

Zhang R, Wang J, Zhao L, Liu S, Du D, Ding H, Chen S, Yue L, Liu YC, Zhang C, Liu H, Luo C. Zhang R, et al. Among authors: zhang c. Eur J Med Chem. 2018 Sep 5;157:867-876. doi: 10.1016/j.ejmech.2018.08.026. Epub 2018 Aug 17. Eur J Med Chem. 2018. PMID: 30145373

4

Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors.

Hou Z, Min W, Zhang R, Niu A, Li Y, Cao L, Han J, Luo C, Yang P, Ding H. Hou Z, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2020 May 1;30(9):127061. doi: 10.1016/j.bmcl.2020.127061. Epub 2020 Feb 25. Bioorg Med Chem Lett. 2020. PMID: 32173197

5

Rational design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors.

Xing J, Zhang R, Jiang X, Hu T, Wang X, Qiao G, Wang J, Yang F, Luo X, Chen K, Shen J, Luo C, Jiang H, Zheng M. Xing J, et al. Among authors: zhang r. Eur J Med Chem. 2019 Feb 1;163:281-294. doi: 10.1016/j.ejmech.2018.11.018. Epub 2018 Nov 16. Eur J Med Chem. 2019. PMID: 30529546

6

The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening.

Ye X, Zhang R, Lian F, Zhang W, Lu W, Han J, Zhang N, Jin J, Luo C, Chen K, Ye F, Ding H. Ye X, et al. Among authors: zhang n, zhang r, zhang w. Bioorg Med Chem Lett. 2019 Feb 15;29(4):638-645. doi: 10.1016/j.bmcl.2018.12.035. Epub 2018 Dec 17. Bioorg Med Chem Lett. 2019. PMID: 30626558

7

Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors.

Yang Y, Zhang R, Li Z, Mei L, Wan S, Ding H, Chen Z, Xing J, Feng H, Han J, Jiang H, Zheng M, Luo C, Zhou B. Yang Y, et al. Among authors: zhang r. J Med Chem. 2020 Feb 13;63(3):1337-1360. doi: 10.1021/acs.jmedchem.9b01721. Epub 2020 Jan 28. J Med Chem. 2020. PMID: 31910017

8

Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening.

Tao H, Wang J, Lu W, Zhang R, Xie Y, Liu YC, Liu R, Yue L, Chen K, Jiang H, Zhang Y, Xu X, Luo C. Tao H, et al. Among authors: zhang r, zhang y. RSC Adv. 2019 Feb 8;9(9):4917-4924. doi: 10.1039/c8ra10074h. eCollection 2019 Feb 5. RSC Adv. 2019. PMID: 35514635 Free PMC article.

9

Computer-Aided Drug Design in Epigenetics.

Lu W, Zhang R, Jiang H, Zhang H, Luo C. Lu W, et al. Among authors: zhang r, zhang h. Front Chem. 2018 Mar 12;6:57. doi: 10.3389/fchem.2018.00057. eCollection 2018. Front Chem. 2018. PMID: 29594101 Free PMC article. Review.

10

Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.

Sun Z, Zhang H, Zhang Y, Liao L, Zhou W, Zhang F, Lian F, Huang J, Xu P, Zhang R, Lu W, Zhu M, Tao H, Yang F, Ding H, Chen S, Yue L, Zhou B, Zhang N, Tan M, Jiang H, Chen K, Liu B, Liu C, Dang Y, Luo C. Sun Z, et al. Among authors: zhang n, zhang r, zhang f, zhang h, zhang y. Adv Sci (Weinh). 2020 May 13;7(14):2000098. doi: 10.1002/advs.202000098. eCollection 2020 Jul. Adv Sci (Weinh). 2020. PMID: 32714746 Free PMC article.

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