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Efficacy of (S)-Lacosamide in preclinical models of cephalic pain.
Moutal A, Eyde N, Telemi E, Park KD, Xie JY, Dodick DW, Porreca F, Khanna R. Moutal A, et al. Among authors: park kd. Pain Rep. 2016 Jun;1(1):e565. doi: 10.1097/PR9.0000000000000565. Pain Rep. 2016. PMID: 27917413 Free PMC article.
In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation.
Wang Y, Brittain JM, Jarecki BW, Park KD, Wilson SM, Wang B, Hale R, Meroueh SO, Cummins TR, Khanna R. Wang Y, et al. Among authors: park kd. J Biol Chem. 2010 Aug 13;285(33):25296-307. doi: 10.1074/jbc.M110.128801. Epub 2010 Jun 9. J Biol Chem. 2010. PMID: 20538611 Free PMC article.
Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-gated Sodium Channels and in the Treatment of Neuropathic Pain.
Wang Y, Wilson SM, Brittain JM, Ripsch MS, Salomé C, Park KD, White FA, Khanna R, Kohn H. Wang Y, et al. Among authors: park kd. ACS Chem Neurosci. 2011 Jun 15;2(6):317-322. doi: 10.1021/cn200024z. ACS Chem Neurosci. 2011. PMID: 21765969 Free PMC article.
Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lacosamide and safinamide.
Park KD, Yang XF, Dustrude ET, Wang Y, Ripsch MS, White FA, Khanna R, Kohn H. Park KD, et al. ACS Chem Neurosci. 2015 Feb 18;6(2):316-30. doi: 10.1021/cn5002182. Epub 2014 Dec 9. ACS Chem Neurosci. 2015. PMID: 25418676 Free PMC article.
(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.
Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD, Shrinivasan R, Gilbraith KB, Qu C, Xie JY, Patwardhan A, Vanderah TW, Khanna M, Porreca F, Khanna R. Moutal A, et al. Among authors: park kd. Pain. 2016 Jul;157(7):1448-1463. doi: 10.1097/j.pain.0000000000000555. Pain. 2016. PMID: 26967696 Free PMC article.
CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.
Moutal A, Villa LS, Yeon SK, Householder KT, Park KD, Sirianni RW, Khanna R. Moutal A, et al. Among authors: park kd. Mol Neurobiol. 2018 May;55(5):4403-4416. doi: 10.1007/s12035-017-0653-9. Epub 2017 Jun 28. Mol Neurobiol. 2018. PMID: 28660485 Free PMC article.
697 results