Hugel T - Search Results

1

Multidomain structure and correlated dynamics determined by self-consistent FRET networks.

Hellenkamp B, Wortmann P, Kandzia F, Zacharias M, Hugel T. Hellenkamp B, et al. Among authors: hugel t. Nat Methods. 2017 Feb;14(2):174-180. doi: 10.1038/nmeth.4081. Epub 2016 Dec 5. Nat Methods. 2017. PMID: 27918541 Free PMC article.

2

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis.

Mickler M, Hessling M, Ratzke C, Buchner J, Hugel T. Mickler M, et al. Among authors: hugel t. Nat Struct Mol Biol. 2009 Mar;16(3):281-6. doi: 10.1038/nsmb.1557. Epub 2009 Feb 22. Nat Struct Mol Biol. 2009. PMID: 19234469

3

Dynamics of heat shock protein 90 C-terminal dimerization is an important part of its conformational cycle.

Ratzke C, Mickler M, Hellenkamp B, Buchner J, Hugel T. Ratzke C, et al. Among authors: hugel t. Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16101-6. doi: 10.1073/pnas.1000916107. Epub 2010 Aug 24. Proc Natl Acad Sci U S A. 2010. PMID: 20736353 Free PMC article.

4

Heat shock protein 90's mechanochemical cycle is dominated by thermal fluctuations.

Ratzke C, Berkemeier F, Hugel T. Ratzke C, et al. Among authors: hugel t. Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):161-6. doi: 10.1073/pnas.1107930108. Epub 2011 Dec 19. Proc Natl Acad Sci U S A. 2012. PMID: 22184223 Free PMC article.

5

From a ratchet mechanism to random fluctuations evolution of Hsp90's mechanochemical cycle.

Ratzke C, Nguyen MN, Mayer MP, Hugel T. Ratzke C, et al. Among authors: hugel t. J Mol Biol. 2012 Oct 26;423(3):462-71. doi: 10.1016/j.jmb.2012.07.026. Epub 2012 Aug 6. J Mol Biol. 2012. PMID: 22878379

6

Nucleotides and substrates trigger the dynamics of the Toc34 GTPase homodimer involved in chloroplast preprotein translocation.

Lumme C, Altan-Martin H, Dastvan R, Sommer MS, Oreb M, Schuetz D, Hellenkamp B, Mirus O, Kretschmer J, Lyubenova S, Kügel W, Medelnik JP, Dehmer M, Michaelis J, Prisner TF, Hugel T, Schleiff E. Lumme C, et al. Among authors: hugel t. Structure. 2014 Apr 8;22(4):526-38. doi: 10.1016/j.str.2014.02.004. Epub 2014 Mar 13. Structure. 2014. PMID: 24631462 Free article.

7

Four-colour FRET reveals directionality in the Hsp90 multicomponent machinery.

Ratzke C, Hellenkamp B, Hugel T. Ratzke C, et al. Among authors: hugel t. Nat Commun. 2014 Jun 20;5:4192. doi: 10.1038/ncomms5192. Nat Commun. 2014. PMID: 24947016 Free article.

8

The charged linker of the molecular chaperone Hsp90 modulates domain contacts and biological function.

Jahn M, Rehn A, Pelz B, Hellenkamp B, Richter K, Rief M, Buchner J, Hugel T. Jahn M, et al. Among authors: hugel t. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):17881-6. doi: 10.1073/pnas.1414073111. Epub 2014 Dec 2. Proc Natl Acad Sci U S A. 2014. PMID: 25468961 Free PMC article.

9

Mechanism of Reversible Peptide-Bilayer Attachment: Combined Simulation and Experimental Single-Molecule Study.

Schwierz N, Krysiak S, Hugel T, Zacharias M. Schwierz N, et al. Among authors: hugel t. Langmuir. 2016 Jan 26;32(3):810-21. doi: 10.1021/acs.langmuir.5b03435. Epub 2016 Jan 12. Langmuir. 2016. PMID: 26717083

10

Folding and assembly of the large molecular machine Hsp90 studied in single-molecule experiments.

Jahn M, Buchner J, Hugel T, Rief M. Jahn M, et al. Among authors: hugel t. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1232-7. doi: 10.1073/pnas.1518827113. Epub 2016 Jan 19. Proc Natl Acad Sci U S A. 2016. PMID: 26787848 Free PMC article.

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