Vocadlo DJ - Search Results

1

Genome-wide chemical mapping of O-GlcNAcylated proteins in Drosophila melanogaster.

Liu TW, Myschyshyn M, Sinclair DA, Cecioni S, Beja K, Honda BM, Morin RD, Vocadlo DJ. Liu TW, et al. Among authors: vocadlo dj. Nat Chem Biol. 2017 Feb;13(2):161-167. doi: 10.1038/nchembio.2247. Epub 2016 Dec 5. Nat Chem Biol. 2017. PMID: 27918560

2

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.

Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ, He Y, Whitworth GE, Stubbs KA, McEachern EJ, Davies GJ, Vocadlo DJ. Yuzwa SA, et al. Among authors: vocadlo dj. Nat Chem Biol. 2008 Aug;4(8):483-90. doi: 10.1038/nchembio.96. Epub 2008 Jun 29. Nat Chem Biol. 2008. PMID: 18587388

3

Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).

Sinclair DA, Syrzycka M, Macauley MS, Rastgardani T, Komljenovic I, Vocadlo DJ, Brock HW, Honda BM. Sinclair DA, et al. Among authors: vocadlo dj. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13427-32. doi: 10.1073/pnas.0904638106. Epub 2009 Jul 28. Proc Natl Acad Sci U S A. 2009. PMID: 19666537 Free PMC article.

4

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells.

Gloster TM, Zandberg WF, Heinonen JE, Shen DL, Deng L, Vocadlo DJ. Gloster TM, et al. Among authors: vocadlo dj. Nat Chem Biol. 2011 Mar;7(3):174-81. doi: 10.1038/nchembio.520. Epub 2011 Jan 23. Nat Chem Biol. 2011. PMID: 21258330 Free PMC article.

5

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

Yuzwa SA, Shan X, Macauley MS, Clark T, Skorobogatko Y, Vosseller K, Vocadlo DJ. Yuzwa SA, et al. Among authors: vocadlo dj. Nat Chem Biol. 2012 Feb 26;8(4):393-9. doi: 10.1038/nchembio.797. Nat Chem Biol. 2012. PMID: 22366723

6

Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology.

Gloster TM, Vocadlo DJ. Gloster TM, et al. Among authors: vocadlo dj. Nat Chem Biol. 2012 Jul 18;8(8):683-94. doi: 10.1038/nchembio.1029. Nat Chem Biol. 2012. PMID: 22810773 Review.

7

O-GlcNAc processing enzymes: catalytic mechanisms, substrate specificity, and enzyme regulation.

Vocadlo DJ. Vocadlo DJ. Curr Opin Chem Biol. 2012 Dec;16(5-6):488-97. doi: 10.1016/j.cbpa.2012.10.021. Epub 2012 Nov 10. Curr Opin Chem Biol. 2012. PMID: 23146438 Review.

8

Tools for probing and perturbing O-GlcNAc in cells and in vivo.

Cecioni S, Vocadlo DJ. Cecioni S, et al. Among authors: vocadlo dj. Curr Opin Chem Biol. 2013 Oct;17(5):719-28. doi: 10.1016/j.cbpa.2013.06.030. Epub 2013 Jul 30. Curr Opin Chem Biol. 2013. PMID: 23906602 Review.

9

O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond.

Yuzwa SA, Vocadlo DJ. Yuzwa SA, et al. Among authors: vocadlo dj. Chem Soc Rev. 2014 Oct 7;43(19):6839-58. doi: 10.1039/c4cs00038b. Epub 2014 Apr 24. Chem Soc Rev. 2014. PMID: 24759912 Review.

10

O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains.

Zhu Y, Liu TW, Cecioni S, Eskandari R, Zandberg WF, Vocadlo DJ. Zhu Y, et al. Among authors: vocadlo dj. Nat Chem Biol. 2015 May;11(5):319-25. doi: 10.1038/nchembio.1774. Epub 2015 Mar 16. Nat Chem Biol. 2015. PMID: 25774941

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