Cooke RM - Search Results

1

Intracellular allosteric antagonism of the CCR9 receptor.

Oswald C, Rappas M, Kean J, Doré AS, Errey JC, Bennett K, Deflorian F, Christopher JA, Jazayeri A, Mason JS, Congreve M, Cooke RM, Marshall FH. Oswald C, et al. Among authors: cooke rm. Nature. 2016 Dec 15;540(7633):462-465. doi: 10.1038/nature20606. Epub 2016 Dec 7. Nature. 2016. PMID: 27926729

2

Preparation of purified GPCRs for structural studies.

Cooke RM, Koglin M, Errey JC, Marshall FH. Cooke RM, et al. Biochem Soc Trans. 2013 Feb 1;41(1):185-90. doi: 10.1042/BST20120240. Biochem Soc Trans. 2013. PMID: 23356281

3

Structure of class B GPCR corticotropin-releasing factor receptor 1.

Hollenstein K, Kean J, Bortolato A, Cheng RK, Doré AS, Jazayeri A, Cooke RM, Weir M, Marshall FH. Hollenstein K, et al. Among authors: cooke rm. Nature. 2013 Jul 25;499(7459):438-43. doi: 10.1038/nature12357. Epub 2013 Jul 17. Nature. 2013. PMID: 23863939

4

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.

Doré AS, Okrasa K, Patel JC, Serrano-Vega M, Bennett K, Cooke RM, Errey JC, Jazayeri A, Khan S, Tehan B, Weir M, Wiggin GR, Marshall FH. Doré AS, et al. Among authors: cooke rm. Nature. 2014 Jul 31;511(7511):557-62. doi: 10.1038/nature13396. Epub 2014 Jul 6. Nature. 2014. PMID: 25042998

5

Biosensor-based affinities and binding kinetics of small molecule antagonists to the adenosine A(2A) receptor reconstituted in HDL like particles.

Segala E, Errey JC, Fiez-Vandal C, Zhukov A, Cooke RM. Segala E, et al. Among authors: cooke rm. FEBS Lett. 2015 Jun 4;589(13):1399-405. doi: 10.1016/j.febslet.2015.04.030. Epub 2015 Apr 29. FEBS Lett. 2015. PMID: 25935416 Free article.

6

Purification of Stabilized GPCRs for Structural and Biophysical Analyses.

Errey JC, Doré AS, Zhukov A, Marshall FH, Cooke RM. Errey JC, et al. Among authors: cooke rm. Methods Mol Biol. 2015;1335:1-15. doi: 10.1007/978-1-4939-2914-6_1. Methods Mol Biol. 2015. PMID: 26260590

7

Structures of G protein-coupled receptors reveal new opportunities for drug discovery.

Cooke RM, Brown AJ, Marshall FH, Mason JS. Cooke RM, et al. Drug Discov Today. 2015 Nov;20(11):1355-64. doi: 10.1016/j.drudis.2015.08.003. Epub 2015 Aug 22. Drug Discov Today. 2015. PMID: 26303408 Review.

8

Extra-helical binding site of a glucagon receptor antagonist.

Jazayeri A, Doré AS, Lamb D, Krishnamurthy H, Southall SM, Baig AH, Bortolato A, Koglin M, Robertson NJ, Errey JC, Andrews SP, Teobald I, Brown AJ, Cooke RM, Weir M, Marshall FH. Jazayeri A, et al. Among authors: cooke rm. Nature. 2016 May 12;533(7602):274-7. doi: 10.1038/nature17414. Epub 2016 Apr 25. Nature. 2016. PMID: 27111510

9

Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength.

Segala E, Guo D, Cheng RK, Bortolato A, Deflorian F, Doré AS, Errey JC, Heitman LH, IJzerman AP, Marshall FH, Cooke RM. Segala E, et al. Among authors: cooke rm. J Med Chem. 2016 Jul 14;59(13):6470-9. doi: 10.1021/acs.jmedchem.6b00653. Epub 2016 Jul 1. J Med Chem. 2016. PMID: 27312113

10

Allosteric binding: structures reveal new ways to tame G protein-coupled receptors.

Cooke R, Congreve M. Cooke R, et al. Future Med Chem. 2016 Nov;8(17):2005-2007. doi: 10.4155/fmc-2016-0167. Epub 2016 Oct 14. Future Med Chem. 2016. PMID: 27739332 No abstract available.

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