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The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells.
Modarai SR, Gupta A, Opdenaker LM, Kowash R, Masters G, Viswanathan V, Zhang T, Fields JZ, Boman BM. Modarai SR, et al. Among authors: opdenaker lm. Oncotarget. 2018 Oct 5;9(78):34658-34669. doi: 10.18632/oncotarget.26157. eCollection 2018 Oct 5. Oncotarget. 2018. PMID: 30410666 Free PMC article.
APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development.
Zhang T, Ahn K, Emerick B, Modarai SR, Opdenaker LM, Palazzo J, Schleiniger G, Fields JZ, Boman BM. Zhang T, et al. Among authors: opdenaker lm. PLoS One. 2020 Oct 28;15(10):e0239601. doi: 10.1371/journal.pone.0239601. eCollection 2020. PLoS One. 2020. PMID: 33112876 Free PMC article.
22 results