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Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers.
Siegrist R, Pozzi D, Jacob G, Torrisi C, Colas K, Braibant B, Mawet J, Pfeifer T, de Kanter R, Roch C, Kessler M, Moon R, Corminboeuf O, Bezençon O. Siegrist R, et al. Among authors: roch c. J Med Chem. 2016 Dec 8;59(23):10661-10675. doi: 10.1021/acs.jmedchem.6b01356. Epub 2016 Nov 23. J Med Chem. 2016. PMID: 27933950
Correction to Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers.
Siegrist R, Pozzi D, Jacob G, Torrisi C, Colas K, Braibant B, Mawet J, Pfeifer T, de Kanter R, Roch C, Kessler M, Moon R, Corminboeuf O, Bezençon O. Siegrist R, et al. Among authors: roch c. J Med Chem. 2017 Mar 9;60(5):2163. doi: 10.1021/acs.jmedchem.7b00219. Epub 2017 Feb 24. J Med Chem. 2017. PMID: 28234473 No abstract available.
Discovery and evaluation of Cav3.1-selective T-type calcium channel blockers.
Bezençon O, Remeň L, Richard S, Roch C, Kessler M, Moon R, Mawet J, Ertel EA, Pfeifer T, Capeleto B. Bezençon O, et al. Among authors: roch c. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5322-5325. doi: 10.1016/j.bmcl.2017.09.063. Epub 2017 Oct 3. Bioorg Med Chem Lett. 2017. PMID: 29066309
Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies.
Bezençon O, Siegrist R, Heidmann B, Pozzi D, Stamm S, Remeň L, Richard S, Simons L, Gaston R, Downing D, Grisostomi C, Roch C, Kessler M, Gatfield J, Moon R, Pfeifer T, Mosbacher J, Reymond I, Ertel EA, de Kanter R, Capeleto B, Fournier E, Rey M, Moccia L, Toeroek-Schafroth M, Roscher R, Schindelholz B. Bezençon O, et al. Among authors: roch c. Chimia (Aarau). 2017 Oct 25;71(10):722-729. doi: 10.2533/chimia.2017.722. Chimia (Aarau). 2017. PMID: 29070417 Free article.
Discovery and evaluation of Cav3.2-selective T-type calcium channel blockers.
Bezençon O, Remeň L, Richard S, Roch C, Kessler M, Ertel EA, Moon R, Mawet J, Pfeifer T, Capeleto B. Bezençon O, et al. Among authors: roch c. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5326-5331. doi: 10.1016/j.bmcl.2017.09.062. Epub 2017 Sep 30. Bioorg Med Chem Lett. 2017. PMID: 29074257
Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.
Bezençon O, Heidmann B, Siegrist R, Stamm S, Richard S, Pozzi D, Corminboeuf O, Roch C, Kessler M, Ertel EA, Reymond I, Pfeifer T, de Kanter R, Toeroek-Schafroth M, Moccia LG, Mawet J, Moon R, Rey M, Capeleto B, Fournier E. Bezençon O, et al. Among authors: roch c. J Med Chem. 2017 Dec 14;60(23):9769-9789. doi: 10.1021/acs.jmedchem.7b01236. Epub 2017 Nov 20. J Med Chem. 2017. PMID: 29116786
Recent trends in orexin research--2010 to 2015.
Boss C, Roch C. Boss C, et al. Among authors: roch c. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2875-87. doi: 10.1016/j.bmcl.2015.05.012. Epub 2015 May 15. Bioorg Med Chem Lett. 2015. PMID: 26045032 Review.
57 results