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Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy.
Poe MM, Methuku KR, Li G, Verma AR, Teske KA, Stafford DC, Arnold LA, Cramer JW, Jones TM, Cerne R, Krambis MJ, Witkin JM, Jambrina E, Rehman S, Ernst M, Cook JM, Schkeryantz JM. Poe MM, et al. Among authors: rehman s. J Med Chem. 2016 Dec 8;59(23):10800-10806. doi: 10.1021/acs.jmedchem.6b01332. Epub 2016 Nov 28. J Med Chem. 2016. PMID: 27933953 Free PMC article.
Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the α5 subunit.
Stamenić TT, Poe MM, Rehman S, Santrač A, Divović B, Scholze P, Ernst M, Cook JM, Savić MM. Stamenić TT, et al. Among authors: rehman s. Eur J Pharmacol. 2016 Nov 15;791:433-443. doi: 10.1016/j.ejphar.2016.09.016. Epub 2016 Sep 14. Eur J Pharmacol. 2016. PMID: 27639297 Free PMC article.
Variations on a scaffold - Novel GABAA receptor modulators.
Iorio MT, Rehman S, Bampali K, Stoeger B, Schnürch M, Ernst M, Mihovilovic MD. Iorio MT, et al. Among authors: rehman s. Eur J Med Chem. 2019 Oct 15;180:340-349. doi: 10.1016/j.ejmech.2019.07.008. Epub 2019 Jul 5. Eur J Med Chem. 2019. PMID: 31325782 Free article.
Erratum to "Defined concatenated α6α1β3γ2 GABAA receptor constructs reveal dual action of pyrazoloquinolinone allosteric modulators" [Bioorg. Med. Chem. 27 (2019) 3167-3178].
Simeone X, Iorio MT, Siebert DCB, Rehman S, Schnürch M, Mihovilovic MD, Ernst M. Simeone X, et al. Among authors: rehman s. Bioorg Med Chem. 2020 Apr 15;28(8):115417. doi: 10.1016/j.bmc.2020.115417. Epub 2020 Mar 14. Bioorg Med Chem. 2020. PMID: 32184041 No abstract available.
1,738 results