Schadt S - Search Results

1

In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA.

Zell M, Husser C, Staack RF, Jordan G, Richter WF, Schadt S, Pähler A. Zell M, et al. Among authors: schadt s. Anal Chem. 2016 Dec 6;88(23):11670-11677. doi: 10.1021/acs.analchem.6b03252. Epub 2016 Nov 18. Anal Chem. 2016. PMID: 27934109

2

A double-tracer technique to characterize absorption, distribution, metabolism and excretion (ADME) of [¹⁴C]-basimglurant and absolute bioavailability after oral administration and concomitant intravenous microdose administration of [¹³C₆]-labeled basimglurant in humans.

Guerini E, Schadt S, Greig G, Haas R, Husser C, Zell M, Funk C, Hartung T, Gloge A, Mallalieu NL. Guerini E, et al. Among authors: schadt s. Xenobiotica. 2017 Feb;47(2):144-153. doi: 10.3109/00498254.2016.1169334. Epub 2016 Apr 28. Xenobiotica. 2017. PMID: 27123695

3

Minimizing the risk of chemically reactive metabolite formation of new drug candidates: implications for preclinical drug design.

Brink A, Pähler A, Funk C, Schuler F, Schadt S. Brink A, et al. Among authors: schadt s. Drug Discov Today. 2017 May;22(5):751-756. doi: 10.1016/j.drudis.2016.11.018. Epub 2016 Nov 27. Drug Discov Today. 2017. PMID: 27903430

4

Identification of GalNAc-Conjugated Antisense Oligonucleotide Metabolites Using an Untargeted and Generic Approach Based on High Resolution Mass Spectrometry.

Husser C, Brink A, Zell M, Müller MB, Koller E, Schadt S. Husser C, et al. Among authors: schadt s. Anal Chem. 2017 Jun 20;89(12):6821-6826. doi: 10.1021/acs.analchem.7b01244. Epub 2017 May 25. Anal Chem. 2017. PMID: 28520401

5

Profiling of dalcetrapib metabolites in human plasma by accelerator mass spectrometry and investigation of the free phenothiol by derivatisation with methylacrylate.

Husser C, Pähler A, Seymour M, Kuhlmann O, Schadt S, Zell M. Husser C, et al. Among authors: schadt s. J Pharm Biomed Anal. 2018 Apr 15;152:143-154. doi: 10.1016/j.jpba.2018.01.022. Epub 2018 Jan 12. J Pharm Biomed Anal. 2018. PMID: 29414006

6

The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1.

Schadt S, Husser C, Staack RF, Ekiciler A, Qiu NH, Fowler S, Funk C, Kratochwil NA. Schadt S, et al. Sci Rep. 2019 Mar 11;9(1):4074. doi: 10.1038/s41598-019-40542-5. Sci Rep. 2019. PMID: 30858459 Free PMC article.

7

Studying the Biotransformation of Phosphorothioate-Containing Oligonucleotide Drugs by LC-MS.

Husser C, Koller E, Brink A, Schadt S. Husser C, et al. Among authors: schadt s. Methods Mol Biol. 2019;2036:307-315. doi: 10.1007/978-1-4939-9670-4_18. Methods Mol Biol. 2019. PMID: 31410805

8

Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges.

Schadt S, Hauri S, Lopes F, Edelmann MR, Staack RF, Villaseñor R, Kettenberger H, Roth AB, Schuler F, Richter WF, Funk C. Schadt S, et al. Drug Metab Dispos. 2019 Dec;47(12):1443-1456. doi: 10.1124/dmd.119.088997. Drug Metab Dispos. 2019. PMID: 31748266

9

Absolute Bioavailability of Vemurafenib in Patients With BRAF^V600 Mutation-Positive Malignancies.

Zhang W, Colburn D, Simmons B, Papai Z, Bertran E, Schadt S, Husser C, Forbes H, Roethlisberger D, Hartung T. Zhang W, et al. Among authors: schadt s. Clin Pharmacol Drug Dev. 2020 May;9(4):496-504. doi: 10.1002/cpdd.773. Epub 2020 Feb 21. Clin Pharmacol Drug Dev. 2020. PMID: 32083398 Clinical Trial.

10

Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats.

Romero-Palomo F, Festag M, Lenz B, Schadt S, Brink A, Kipar A, Steinhuber B, Husser C, Koller E, Sewing S, Tessier Y, Dzygiel P, Fischer G, Winter M, Hetzel U, Mihatsch MJ, Braendli-Baiocco A. Romero-Palomo F, et al. Among authors: schadt s. Toxicol Pathol. 2021 Aug;49(6):1174-1192. doi: 10.1177/01926233211011615. Epub 2021 Jun 1. Toxicol Pathol. 2021. PMID: 34060347

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