Shen DL - Search Results

1

Catalytic Promiscuity of O-GlcNAc Transferase Enables Unexpected Metabolic Engineering of Cytoplasmic Proteins with 2-Azido-2-deoxy-glucose.

Shen DL, Liu TW, Zandberg W, Clark T, Eskandari R, Alteen MG, Tan HY, Zhu Y, Cecioni S, Vocadlo D. Shen DL, et al. ACS Chem Biol. 2017 Jan 20;12(1):206-213. doi: 10.1021/acschembio.6b00876. Epub 2016 Dec 9. ACS Chem Biol. 2017. PMID: 27935279

2

Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates.

Shen DL, Gloster TM, Yuzwa SA, Vocadlo DJ. Shen DL, et al. J Biol Chem. 2012 May 4;287(19):15395-408. doi: 10.1074/jbc.M111.310664. Epub 2012 Feb 6. J Biol Chem. 2012. PMID: 22311971 Free PMC article.

3

A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High-Throughput Screening: Application to O-GlcNAc Transferase.

Alteen MG, Gros C, Meek RW, Cardoso DA, Busmann JA, Sangouard G, Deen MC, Tan HY, Shen DL, Russell CC, Davies GJ, Robinson PJ, McCluskey A, Vocadlo DJ. Alteen MG, et al. Among authors: shen dl. Angew Chem Int Ed Engl. 2020 Jun 8;59(24):9601-9609. doi: 10.1002/anie.202000621. Epub 2020 Apr 2. Angew Chem Int Ed Engl. 2020. PMID: 32092778

4

Direct One-Step Fluorescent Labeling of O-GlcNAc-Modified Proteins in Live Cells Using Metabolic Intermediates.

Tan HY, Eskandari R, Shen D, Zhu Y, Liu TW, Willems LI, Alteen MG, Madden Z, Vocadlo DJ. Tan HY, et al. J Am Chem Soc. 2018 Nov 14;140(45):15300-15308. doi: 10.1021/jacs.8b08260. Epub 2018 Oct 22. J Am Chem Soc. 2018. PMID: 30296064 Free article.

5

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells.

Gloster TM, Zandberg WF, Heinonen JE, Shen DL, Deng L, Vocadlo DJ. Gloster TM, et al. Among authors: shen dl. Nat Chem Biol. 2011 Mar;7(3):174-81. doi: 10.1038/nchembio.520. Epub 2011 Jan 23. Nat Chem Biol. 2011. PMID: 21258330 Free PMC article.

6

Selective Fluorogenic β-Glucocerebrosidase Substrates for Convenient Analysis of Enzyme Activity in Cell and Tissue Homogenates.

Deen MC, Proceviat C, Shan X, Wu L, Shen DL, Davies GJ, Vocadlo DJ. Deen MC, et al. Among authors: shen dl. ACS Chem Biol. 2020 Apr 17;15(4):824-829. doi: 10.1021/acschembio.9b01044. Epub 2020 Mar 16. ACS Chem Biol. 2020. PMID: 32109051 Free article.

7

Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation.

Martinez-Fleites C, Macauley MS, He Y, Shen DL, Vocadlo DJ, Davies GJ. Martinez-Fleites C, et al. Among authors: shen dl. Nat Struct Mol Biol. 2008 Jul;15(7):764-5. doi: 10.1038/nsmb.1443. Epub 2008 Jun 8. Nat Struct Mol Biol. 2008. PMID: 18536723

8

Fluorescence-quenched substrates for live cell imaging of human glucocerebrosidase activity.

Yadav AK, Shen DL, Shan X, He X, Kermode AR, Vocadlo DJ. Yadav AK, et al. Among authors: shen dl. J Am Chem Soc. 2015 Jan 28;137(3):1181-9. doi: 10.1021/ja5106738. Epub 2015 Jan 15. J Am Chem Soc. 2015. PMID: 25562638

9

Fluorescence-Quenched Substrates for Quantitative Live Cell Imaging of Glucocerebrosidase Activity.

Ashmus RA, Shen DL, Vocadlo DJ. Ashmus RA, et al. Among authors: shen dl. Methods Enzymol. 2018;598:199-215. doi: 10.1016/bs.mie.2017.06.014. Epub 2017 Oct 31. Methods Enzymol. 2018. PMID: 29306435

10

Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms.

Kolappan S, Shen DL, Mosi R, Sun J, McEachern EJ, Vocadlo DJ, Craig L. Kolappan S, et al. Among authors: shen dl. Acta Crystallogr D Biol Crystallogr. 2015 Feb;71(Pt 2):185-95. doi: 10.1107/S1399004714024791. Epub 2015 Jan 23. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 25664730

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