You W - Search Results

1

Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.

You W, Rotili D, Li TM, Kambach C, Meleshin M, Schutkowski M, Chua KF, Mai A, Steegborn C. You W, et al. Angew Chem Int Ed Engl. 2017 Jan 19;56(4):1007-1011. doi: 10.1002/anie.201610082. Epub 2016 Dec 19. Angew Chem Int Ed Engl. 2017. PMID: 27990725

2

Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A: Implications for Protein Deacylase Drug Development.

You W, Steegborn C. You W, et al. J Med Chem. 2018 Dec 13;61(23):10922-10928. doi: 10.1021/acs.jmedchem.8b01455. Epub 2018 Nov 15. J Med Chem. 2018. PMID: 30395713

3

Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.

You W, Zheng W, Weiss S, Chua KF, Steegborn C. You W, et al. Sci Rep. 2019 Dec 16;9(1):19176. doi: 10.1038/s41598-019-55654-1. Sci Rep. 2019. PMID: 31844103 Free PMC article.

4

Structural Basis for Activation of Human Sirtuin 6 by Fluvastatin.

You W, Steegborn C. You W, et al. ACS Med Chem Lett. 2020 Sep 24;11(11):2285-2289. doi: 10.1021/acsmedchemlett.0c00407. eCollection 2020 Nov 12. ACS Med Chem Lett. 2020. PMID: 33214841 Free PMC article.

5

Binding site for activator MDL-801 on SIRT6.

You W, Steegborn C. You W, et al. Nat Chem Biol. 2021 May;17(5):519-521. doi: 10.1038/s41589-021-00749-y. Epub 2021 Mar 1. Nat Chem Biol. 2021. PMID: 33649599 No abstract available.

6

Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development.

You W, Montoya AL, Dana S, Franzini RM, Steegborn C. You W, et al. ChemMedChem. 2024 Oct 16;19(20):e202400273. doi: 10.1002/cmdc.202400273. Epub 2024 Aug 19. ChemMedChem. 2024. PMID: 38940296 Free PMC article.

7

Structure-Guided Discovery of Novel N⁴-(Substituted Thiazol-2-yl)-N²-(4-Substituted phenyl)pyrimidine-2,4-Diamines as Potent CDK2 and CDK9 Dual Inhibitors with High Oral Bioavailability.

Zhang B, Li Y, Lin Y, Wang T, Chen L, Cai J, Ji T, Diao P, Ma Y, Zhang Y, You W, Chen J, Zhao P. Zhang B, et al. Among authors: you w. J Med Chem. 2025 Jan 8. doi: 10.1021/acs.jmedchem.4c02441. Online ahead of print. J Med Chem. 2025. PMID: 39772543

8

The Safety and Immunogenicity of a 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine (CRM197/TT) in Infants: A Double-Blind, Randomized, Phase III Trial.

Xie Z, Li J, Wang X, Huang L, Gou J, Zhang W, Huang H, You W, Wang F, Li X, Zhang J, Han Q, Ma X, Wang Y. Xie Z, et al. Among authors: you w. Vaccines (Basel). 2024 Dec 16;12(12):1417. doi: 10.3390/vaccines12121417. Vaccines (Basel). 2024. PMID: 39772078

9

Disparities in treatment delays among metastatic breast cancer patients: insights from nationwide electronic health records, 2011-2022.

Pilehvari A, You W, Kimmick G, Bonilla G, Anderson R. Pilehvari A, et al. Among authors: you w. Breast Cancer Res Treat. 2025 Jan 7. doi: 10.1007/s10549-024-07593-3. Online ahead of print. Breast Cancer Res Treat. 2025. PMID: 39762708

10

Nuclear transmembrane protein 199 promotes immune escapes by up-regulating programmed death ligand 1.

You W, Luu H, Li M, Chen Z, Li F, Zhang Y, Cai M, He TC, Li J. You W, et al. iScience. 2024 Nov 28;27(12):111485. doi: 10.1016/j.isci.2024.111485. eCollection 2024 Dec 20. iScience. 2024. PMID: 39758995 Free PMC article.

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