Dimitrov M - Search Results

1

Shedding of neurexin 3β ectodomain by ADAM10 releases a soluble fragment that affects the development of newborn neurons.

Borcel E, Palczynska M, Krzisch M, Dimitrov M, Ulrich G, Toni N, Fraering PC. Borcel E, et al. Among authors: dimitrov m. Sci Rep. 2016 Dec 19;6:39310. doi: 10.1038/srep39310. Sci Rep. 2016. PMID: 27991559 Free PMC article.

2

Highly efficient production of the Alzheimer's γ-secretase integral membrane protease complex by a multi-gene stable integration approach.

Alattia JR, Matasci M, Dimitrov M, Aeschbach L, Balasubramanian S, Hacker DL, Wurm FM, Fraering PC. Alattia JR, et al. Among authors: dimitrov m. Biotechnol Bioeng. 2013 Jul;110(7):1995-2005. doi: 10.1002/bit.24851. Epub 2013 Feb 15. Biotechnol Bioeng. 2013. PMID: 23359429

3

Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production.

Dimitrov M, Alattia JR, Lemmin T, Lehal R, Fligier A, Houacine J, Hussain I, Radtke F, Dal Peraro M, Beher D, Fraering PC. Dimitrov M, et al. Nat Commun. 2013;4:2246. doi: 10.1038/ncomms3246. Nat Commun. 2013. PMID: 23907250 Free article.

4

Perturbations of the straight transmembrane α-helical structure of the amyloid precursor protein affect its processing by γ-secretase.

Lemmin T, Dimitrov M, Fraering PC, Dal Peraro M. Lemmin T, et al. Among authors: dimitrov m. J Biol Chem. 2014 Mar 7;289(10):6763-6774. doi: 10.1074/jbc.M113.470781. Epub 2014 Jan 27. J Biol Chem. 2014. PMID: 24469457 Free PMC article.

5

The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain.

Mosser S, Alattia JR, Dimitrov M, Matz A, Pascual J, Schneider BL, Fraering PC. Mosser S, et al. Among authors: dimitrov m. Hum Mol Genet. 2015 Jan 15;24(2):371-82. doi: 10.1093/hmg/ddu449. Epub 2014 Sep 1. Hum Mol Genet. 2015. PMID: 25180020 Free PMC article.

6

Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.

Matz A, Halamoda-Kenzaoui B, Hamelin R, Mosser S, Alattia JR, Dimitrov M, Moniatte M, Fraering PC. Matz A, et al. Among authors: dimitrov m. J Neurochem. 2015 May;133(3):409-21. doi: 10.1111/jnc.12996. Epub 2015 Feb 24. J Neurochem. 2015. PMID: 25458374 Free article.

7

Production of active glycosylation-deficient γ-secretase complex for crystallization studies.

López AR, Dimitrov M, Gerber H, Braman V, Hacker DL, Wurm FM, Fraering PC. López AR, et al. Among authors: dimitrov m. Biotechnol Bioeng. 2015 Dec;112(12):2516-26. doi: 10.1002/bit.25675. Epub 2015 Jul 14. Biotechnol Bioeng. 2015. PMID: 26059427

8

Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production.

Gerber H, Wu F, Dimitrov M, Garcia Osuna GM, Fraering PC. Gerber H, et al. Among authors: dimitrov m. J Biol Chem. 2017 Mar 3;292(9):3751-3767. doi: 10.1074/jbc.M116.754101. Epub 2017 Jan 17. J Biol Chem. 2017. PMID: 28096459 Free PMC article.

9

Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila.

Alattia JR, Kuraishi T, Dimitrov M, Chang I, Lemaitre B, Fraering PC. Alattia JR, et al. Among authors: dimitrov m. FASEB J. 2011 Jul;25(7):2287-95. doi: 10.1096/fj.10-174078. Epub 2011 Mar 17. FASEB J. 2011. PMID: 21415381

10

Generation of monoclonal antibody fragments binding the native γ-secretase complex for use in structural studies.

Alattia JR, Schweizer C, Cacquevel M, Dimitrov M, Aeschbach L, Oulad-Abdelghani M, Fraering PC. Alattia JR, et al. Among authors: dimitrov m. Biochemistry. 2012 Nov 6;51(44):8779-90. doi: 10.1021/bi300997e. Epub 2012 Oct 25. Biochemistry. 2012. PMID: 23066899

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