Lei X - Search Results

1

Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome.

Ren Y, Su Y, Sun L, He S, Meng L, Liao D, Liu X, Ma Y, Liu C, Li S, Ruan H, Lei X, Wang X, Zhang Z. Ren Y, et al. Among authors: lei x. J Med Chem. 2017 Feb 9;60(3):972-986. doi: 10.1021/acs.jmedchem.6b01196. Epub 2017 Jan 5. J Med Chem. 2017. PMID: 27992216

2

Efficient generation of ortho-quinone methide: application to the biomimetic syntheses of (±)-schefflone and tocopherol trimers.

Liao D, Li H, Lei X. Liao D, et al. Among authors: lei x. Org Lett. 2012 Jan 6;14(1):18-21. doi: 10.1021/ol202641y. Epub 2011 Nov 2. Org Lett. 2012. PMID: 22047096

3

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.

Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X. Sun L, et al. Among authors: lei x. Cell. 2012 Jan 20;148(1-2):213-27. doi: 10.1016/j.cell.2011.11.031. Cell. 2012. PMID: 22265413 Free article.

4

Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine.

Dong T, Li C, Wang X, Dian L, Zhang X, Li L, Chen S, Cao R, Li L, Huang N, He S, Lei X. Dong T, et al. Among authors: lei x. Nat Commun. 2015 Mar 27;6:6522. doi: 10.1038/ncomms7522. Nat Commun. 2015. PMID: 25813672 Free PMC article.

5

Synthesis, cytotoxicity and inhibition of NO production of ivangustin enantiomer analogues.

Qin XY, Chen BY, Fu JJ, Shan L, Lei XG, Zhang WD. Qin XY, et al. Eur J Med Chem. 2015 Sep 18;102:256-65. doi: 10.1016/j.ejmech.2015.07.051. Epub 2015 Aug 1. Eur J Med Chem. 2015. PMID: 26280922

6

Using Small Molecules to Dissect Non-apoptotic Programmed Cell Death: Necroptosis, Ferroptosis, and Pyroptosis.

Dong T, Liao D, Liu X, Lei X. Dong T, et al. Among authors: lei x. Chembiochem. 2015 Dec;16(18):2557-61. doi: 10.1002/cbic.201500422. Epub 2015 Oct 16. Chembiochem. 2015. PMID: 26388514 Review.

7

Total Synthesis and Structural Reassignment of Aspergillomarasmine A.

Liao D, Yang S, Wang J, Zhang J, Hong B, Wu F, Lei X. Liao D, et al. Among authors: lei x. Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4291-5. doi: 10.1002/anie.201509960. Epub 2015 Nov 23. Angew Chem Int Ed Engl. 2016. PMID: 26592805

8

Access to the 2H-Tetrahydro-4,6-dioxo-1,2-oxazine Ring System from Nitrone via a Tandem Nucleophilic Addition and Transesterification Reaction.

Yang S, Liao D, Tian X, Lei X. Yang S, et al. Among authors: lei x. Org Lett. 2016 Feb 5;18(3):376-9. doi: 10.1021/acs.orglett.5b03374. Epub 2016 Jan 12. Org Lett. 2016. PMID: 26849452

9

Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis.

Li D, Li C, Li L, Chen S, Wang L, Li Q, Wang X, Lei X, Shen Z. Li D, et al. Among authors: lei x. Cell Chem Biol. 2016 Feb 18;23(2):257-266. doi: 10.1016/j.chembiol.2015.08.018. Epub 2016 Jan 28. Cell Chem Biol. 2016. PMID: 27028885 Free article.

10

Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.

Ma G, Wang S, Wu K, Zhang W, Ahmad A, Hao Q, Lei X, Zhang H. Ma G, et al. Among authors: lei x. Bioorg Med Chem. 2021 Jan 1;29:115902. doi: 10.1016/j.bmc.2020.115902. Epub 2020 Dec 3. Bioorg Med Chem. 2021. PMID: 33302045

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