Shen J - Search Results

1

An efficient anticoagulant candidate: Characterization, synthesis and in vivo study of a fondaparinux analogue Rrt1.17.

Zhang GQ, Jin H, Zhao Y, Guo L, Gao X, Wang X, Tie S, Shen J, Wang PG, Gan H, Cui H, Zhao W. Zhang GQ, et al. Among authors: shen j. Eur J Med Chem. 2017 Jan 27;126:1039-1055. doi: 10.1016/j.ejmech.2016.12.004. Epub 2016 Dec 2. Eur J Med Chem. 2017. PMID: 28012344

2

Total synthesis of anticoagulant pentasaccharide fondaparinux.

Li T, Ye H, Cao X, Wang J, Liu Y, Zhou L, Liu Q, Wang W, Shen J, Zhao W, Wang P. Li T, et al. Among authors: shen j. ChemMedChem. 2014 May;9(5):1071-80. doi: 10.1002/cmdc.201400019. Epub 2014 Apr 11. ChemMedChem. 2014. PMID: 24729477

3

Structure-based optimization of click-based histone deacetylase inhibitors.

Hou J, Feng C, Li Z, Fang Q, Wang H, Gu G, Shi Y, Liu P, Xu F, Yin Z, Shen J, Wang P. Hou J, et al. Among authors: shen j. Eur J Med Chem. 2011 Aug;46(8):3190-200. doi: 10.1016/j.ejmech.2011.04.027. Epub 2011 Apr 29. Eur J Med Chem. 2011. PMID: 21621883

4

Discovery and extensive in vitro evaluations of NK-HDAC-1: a chiral histone deacetylase inhibitor as a promising lead.

Hou J, Li Z, Fang Q, Feng C, Zhang H, Guo W, Wang H, Gu G, Tian Y, Liu P, Liu R, Lin J, Shi YK, Yin Z, Shen J, Wang PG. Hou J, et al. Among authors: shen j. J Med Chem. 2012 Apr 12;55(7):3066-75. doi: 10.1021/jm201496g. Epub 2012 Mar 30. J Med Chem. 2012. PMID: 22435669

Herein, further SAR studies of lead compound NSC746457 (Shen, J.; Woodward, R.; Kedenburg, J. P.; Liu, X. W.; Chen, M.; Fang, L. Y.; Sun; D. X.; Wang. P. G. J. Med. Chem. 2008, 51, 7417-7427) were performed, including the replacement of the trans-styry …

Herein, further SAR studies of lead compound NSC746457 (Shen, J.; Woodward, R.; Kedenburg, J. P.; Liu, X. W.; Chen, M.; …

5

A sub-milligram-synthesis protocol for in vitro screening of HDAC11 inhibitors.

Tian Y, Jin J, Wang C, Lv W, Li X, Che X, Gong Y, Li Y, Li Q, Hou J, Wang PG, Shen J. Tian Y, et al. Among authors: shen j. Bioorg Med Chem Lett. 2016 May 15;26(10):2434-2437. doi: 10.1016/j.bmcl.2016.03.116. Epub 2016 Apr 1. Bioorg Med Chem Lett. 2016. PMID: 27055940

6

Syntheses and biological activities of rebeccamycin analogues with uncommon sugars.

Zhang G, Shen J, Cheng H, Zhu L, Fang L, Luo S, Muller MT, Lee GE, Wei L, Du Y, Sun D, Wang PG. Zhang G, et al. Among authors: shen j. J Med Chem. 2005 Apr 7;48(7):2600-11. doi: 10.1021/jm0493764. J Med Chem. 2005. PMID: 15801850

7

4-Aryl-1,3,2-oxathiazolylium-5-olate: a novel GST inhibitor to release JNK and activate c-Jun for cancer therapy.

Cui H, Shen J, Lu D, Zhang T, Zhang W, Sun D, Wang PG. Cui H, et al. Among authors: shen j. Cancer Chemother Pharmacol. 2008 Aug;62(3):509-15. doi: 10.1007/s00280-007-0632-3. Epub 2007 Nov 16. Cancer Chemother Pharmacol. 2008. PMID: 18008069

8

Modification on the O-glucoside of Sergliflozin-A: A new strategy for SGLT2 inhibitor design.

Cao X, Zhang W, Yan X, Huang Z, Zhang Z, Wang P, Shen J. Cao X, et al. Among authors: shen j. Bioorg Med Chem Lett. 2016 May 1;26(9):2170-3. doi: 10.1016/j.bmcl.2016.03.065. Epub 2016 Mar 16. Bioorg Med Chem Lett. 2016. PMID: 27025345

9

Stabilizing HDAC11 with SAHA to assay slow-binding benzamide inhibitors.

Tian Y, Lv W, Li X, Wang C, Wang D, Wang PG, Jin J, Shen J. Tian Y, et al. Among authors: shen j. Bioorg Med Chem Lett. 2017 Jul 1;27(13):2943-2945. doi: 10.1016/j.bmcl.2017.05.004. Epub 2017 May 4. Bioorg Med Chem Lett. 2017. PMID: 28501514

10

Syntheses and biological activities of disaccharide daunorubicins.

Zhang G, Fang L, Zhu L, Aimiuwu JE, Shen J, Cheng H, Muller MT, Lee GE, Sun D, Wang PG. Zhang G, et al. Among authors: shen j. J Med Chem. 2005 Aug 11;48(16):5269-78. doi: 10.1021/jm050144u. J Med Chem. 2005. PMID: 16078845

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