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Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.
Iwai K, Yaguchi M, Nishimura K, Yamamoto Y, Tamura T, Nakata D, Dairiki R, Kawakita Y, Mizojiri R, Ito Y, Asano M, Maezaki H, Nakayama Y, Kaishima M, Hayashi K, Teratani M, Miyakawa S, Iwatani M, Miyamoto M, Klein MG, Lane W, Snell G, Tjhen R, He X, Pulukuri S, Nomura T. Iwai K, et al. Among authors: nakata d. EMBO Mol Med. 2018 Jun;10(6):e8289. doi: 10.15252/emmm.201708289. EMBO Mol Med. 2018. PMID: 29769258 Free PMC article.
Elevated expression of free deaminoneuraminic acid in mammalian cells cultured in mannose-rich media.
Angata T, Nakata D, Matsuda T, Kitajima K. Angata T, et al. Among authors: nakata d. Biochem Biophys Res Commun. 1999 Aug 2;261(2):326-31. doi: 10.1006/bbrc.1999.1033. Biochem Biophys Res Commun. 1999. PMID: 10425185
Deaminoneuraminic acid (KDN, 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid) is a member of the family of sialic acids in which an acylamino group at the C-5 position of N-acylneuraminic acid (Neu5Acyl) is replaced by a hydroxyl group. It has recently been shown th …
Deaminoneuraminic acid (KDN, 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid) is a member of the family of sialic acids in whi …
Suppression of the hypothalamic-pituitary-gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: studies in human GnRH receptor knock-in mice.
Nakata D, Masaki T, Tanaka A, Yoshimatsu M, Akinaga Y, Asada M, Sasada R, Takeyama M, Miwa K, Watanabe T, Kusaka M. Nakata D, et al. Eur J Pharmacol. 2014 Jan 15;723:167-74. doi: 10.1016/j.ejphar.2013.12.001. Epub 2013 Dec 11. Eur J Pharmacol. 2014. PMID: 24333551
Pharmacologic profiles of investigational kisspeptin/metastin analogues, TAK-448 and TAK-683, in adult male rats in comparison to the GnRH analogue leuprolide.
Matsui H, Masaki T, Akinaga Y, Kiba A, Takatsu Y, Nakata D, Tanaka A, Ban J, Matsumoto S, Kumano S, Suzuki A, Ikeda Y, Yamaguchi M, Watanabe T, Ohtaki T, Kusaka M. Matsui H, et al. Among authors: nakata d. Eur J Pharmacol. 2014 Jul 15;735:77-85. doi: 10.1016/j.ejphar.2014.03.058. Epub 2014 Apr 18. Eur J Pharmacol. 2014. PMID: 24747751
57 results