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Influence of acute and chronic kidney failure in rats on the disposition and pharmacokinetics of ZYAN1, a novel prolyl hydroxylase inhibitor, for the treatment of chronic kidney disease-induced anemia.
Patel H, Joharapurkar AA, Pandya VB, Patel VJ, Kshirsagar SG, Patel P, Gevriya B, Jain MR, Srinivas NR, Patel PR, Desai RC. Patel H, et al. Among authors: desai rc. Xenobiotica. 2018 Jan;48(1):37-44. doi: 10.1080/00498254.2016.1278287. Epub 2017 Jan 19. Xenobiotica. 2018. PMID: 28042744
Discovery of a Potent and Orally Efficacious TGR5 Receptor Agonist.
Agarwal S, Patil A, Aware U, Deshmukh P, Darji B, Sasane S, Sairam KV, Priyadarsiny P, Giri P, Patel H, Giri S, Jain M, Desai RC. Agarwal S, et al. Among authors: desai rc. ACS Med Chem Lett. 2015 Nov 20;7(1):51-5. doi: 10.1021/acsmedchemlett.5b00323. eCollection 2016 Jan 14. ACS Med Chem Lett. 2015. PMID: 26819665 Free PMC article.
Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist.
Agarwal S, Sasane S, Deshmukh P, Rami B, Bandyopadhyay D, Giri P, Giri S, Jain M, Desai RC. Agarwal S, et al. Among authors: desai rc. ACS Med Chem Lett. 2016 Sep 21;7(12):1134-1138. doi: 10.1021/acsmedchemlett.6b00331. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994752 Free PMC article.
Is the Inhibition of Dipeptidyl Peptidase-4 (DDP-4) Enzyme Route Dependent and/or Driven by High Peak Concentration?- Seeking Answers with ZYDPLA1, a Novel Long Acting DPP-4 Inhibitor, in a Rodent Model.
Patel H, Joharapurkar AA, Bahekar R, Patel P, Kshirsagar SG, Modi N, Ghoghari A, Patel VJ, Jain MR, Srinivas NR, Patel PR, Desai RC. Patel H, et al. Among authors: desai rc. Drug Res (Stuttg). 2017 Apr;67(4):223-227. doi: 10.1055/s-0042-122776. Epub 2017 Feb 3. Drug Res (Stuttg). 2017. PMID: 28158894
57 results