Appella E - Search Results

1

Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.

Veschi V, Liu Z, Voss TC, Ozbun L, Gryder B, Yan C, Hu Y, Ma A, Jin J, Mazur SJ, Lam N, Souza BK, Giannini G, Hager GL, Arrowsmith CH, Khan J, Appella E, Thiele CJ. Veschi V, et al. Among authors: appella e. Cancer Cell. 2017 Jan 9;31(1):50-63. doi: 10.1016/j.ccell.2016.12.002. Cancer Cell. 2017. PMID: 28073004 Free PMC article.

2

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression.

Lin T, Chao C, Saito S, Mazur SJ, Murphy ME, Appella E, Xu Y. Lin T, et al. Among authors: appella e. Nat Cell Biol. 2005 Feb;7(2):165-71. doi: 10.1038/ncb1211. Epub 2004 Dec 26. Nat Cell Biol. 2005. PMID: 15619621

3

p53 N-terminal phosphorylation: a defining layer of complex regulation.

Jenkins LM, Durell SR, Mazur SJ, Appella E. Jenkins LM, et al. Among authors: appella e. Carcinogenesis. 2012 Aug;33(8):1441-9. doi: 10.1093/carcin/bgs145. Epub 2012 Apr 12. Carcinogenesis. 2012. PMID: 22505655 Free PMC article. Review.

4

Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication.

Sakai H, Fujigaki H, Mazur SJ, Appella E. Sakai H, et al. Among authors: appella e. Cell Cycle. 2014;13(6):1015-29. doi: 10.4161/cc.27920. Epub 2014 Jan 31. Cell Cycle. 2014. PMID: 24552809 Free PMC article.

5

Quantitative proteomics analysis of the effects of ionizing radiation in wild type and p53 K317R knock-in mouse thymocytes.

Jenkins LM, Mazur SJ, Rossi M, Gaidarenko O, Xu Y, Appella E. Jenkins LM, et al. Among authors: appella e. Mol Cell Proteomics. 2008 Apr;7(4):716-27. doi: 10.1074/mcp.M700482-MCP200. Epub 2008 Jan 4. Mol Cell Proteomics. 2008. PMID: 18178582 Free PMC article.

6

Radioprobing the conformation of DNA in a p53-DNA complex.

Karamychev VN, Wang D, Mazur SJ, Appella E, Neumann RD, Zhurkin VB, Panyutin IG. Karamychev VN, et al. Among authors: appella e. Int J Radiat Biol. 2012 Dec;88(12):1039-45. doi: 10.3109/09553002.2012.698030. Epub 2012 Jun 21. Int J Radiat Biol. 2012. PMID: 22640875 Free PMC article.

7

Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites.

Rossi M, Demidov ON, Anderson CW, Appella E, Mazur SJ. Rossi M, et al. Among authors: appella e. Nucleic Acids Res. 2008 Dec;36(22):7168-80. doi: 10.1093/nar/gkn888. Epub 2008 Nov 10. Nucleic Acids Res. 2008. PMID: 19015127 Free PMC article.

8

Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain.

Tagad HD, Debnath S, Clausse V, Saha M, Mazur SJ, Appella E, Appella DH. Tagad HD, et al. Among authors: appella dh, appella e. ChemMedChem. 2018 May 8;13(9):894-901. doi: 10.1002/cmdc.201700779. Epub 2018 Apr 6. ChemMedChem. 2018. PMID: 29476592 Free PMC article.

9

Fmoc-based chemical synthesis and selective binding to supercoiled DNA of the p53 C-terminal segment and its phosphorylated and acetylated derivatives.

Teruya K, Murphy AC, Burlin T, Appella E, Mazur SJ. Teruya K, et al. Among authors: appella e. J Pept Sci. 2004 Aug;10(8):479-93. doi: 10.1002/psc.552. J Pept Sci. 2004. PMID: 15347136

10

Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation.

Jenkins LM, Yamaguchi H, Hayashi R, Cherry S, Tropea JE, Miller M, Wlodawer A, Appella E, Mazur SJ. Jenkins LM, et al. Among authors: appella e. Biochemistry. 2009 Feb 17;48(6):1244-55. doi: 10.1021/bi801716h. Biochemistry. 2009. PMID: 19166313 Free PMC article.

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