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Huntingtin-mediated axonal transport requires arginine methylation by PRMT6.
Migazzi A, Scaramuzzino C, Anderson EN, Tripathy D, Hernández IH, Grant RA, Roccuzzo M, Tosatto L, Virlogeux A, Zuccato C, Caricasole A, Ratovitski T, Ross CA, Pandey UB, Lucas JJ, Saudou F, Pennuto M, Basso M. Migazzi A, et al. Among authors: tosatto l. Cell Rep. 2021 Apr 13;35(2):108980. doi: 10.1016/j.celrep.2021.108980. Cell Rep. 2021. PMID: 33852844 Free PMC article.
Pharmacological inactivation of the prion protein by targeting a folding intermediate.
Spagnolli G, Massignan T, Astolfi A, Biggi S, Rigoli M, Brunelli P, Libergoli M, Ianeselli A, Orioli S, Boldrini A, Terruzzi L, Bonaldo V, Maietta G, Lorenzo NL, Fernandez LC, Codeseira YB, Tosatto L, Linsenmeier L, Vignoli B, Petris G, Gasparotto D, Pennuto M, Guella G, Canossa M, Altmeppen HC, Lolli G, Biressi S, Pastor MM, Requena JR, Mancini I, Barreca ML, Faccioli P, Biasini E. Spagnolli G, et al. Among authors: tosatto l. Commun Biol. 2021 Jan 12;4(1):62. doi: 10.1038/s42003-020-01585-x. Commun Biol. 2021. PMID: 33437023 Free PMC article.
The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity.
Plotegher N, Kumar D, Tessari I, Brucale M, Munari F, Tosatto L, Belluzzi E, Greggio E, Bisaglia M, Capaldi S, Aioanei D, Mammi S, Monaco HL, Samo B, Bubacco L. Plotegher N, et al. Among authors: tosatto l. Hum Mol Genet. 2014 Nov 1;23(21):5615-29. doi: 10.1093/hmg/ddu275. Epub 2014 Jun 3. Hum Mol Genet. 2014. PMID: 24895406
Dopamine quinones interact with alpha-synuclein to form unstructured adducts.
Bisaglia M, Tosatto L, Munari F, Tessari I, de Laureto PP, Mammi S, Bubacco L. Bisaglia M, et al. Among authors: tosatto l. Biochem Biophys Res Commun. 2010 Apr 2;394(2):424-8. doi: 10.1016/j.bbrc.2010.03.044. Epub 2010 Mar 10. Biochem Biophys Res Commun. 2010. PMID: 20226175
Covalent α-synuclein dimers: chemico-physical and aggregation properties.
Pivato M, De Franceschi G, Tosatto L, Frare E, Kumar D, Aioanei D, Brucale M, Tessari I, Bisaglia M, Samori B, de Laureto PP, Bubacco L. Pivato M, et al. Among authors: tosatto l. PLoS One. 2012;7(12):e50027. doi: 10.1371/journal.pone.0050027. Epub 2012 Dec 13. PLoS One. 2012. PMID: 23272053 Free PMC article.
Alpha-synuclein pore forming activity upon membrane association.
Tosatto L, Andrighetti AO, Plotegher N, Antonini V, Tessari I, Ricci L, Bubacco L, Dalla Serra M. Tosatto L, et al. Biochim Biophys Acta. 2012 Nov;1818(11):2876-83. doi: 10.1016/j.bbamem.2012.07.007. Epub 2012 Jul 20. Biochim Biophys Acta. 2012. PMID: 22820150 Free article.
80 results