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Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid.
Castiglioni P, Hartley MA, Rossi M, Prevel F, Desponds C, Utzschneider DT, Eren RO, Zangger H, Brunner L, Collin N, Zehn D, Kuhlmann FM, Beverley SM, Fasel N, Ronet C. Castiglioni P, et al. Among authors: kuhlmann fm. PLoS Negl Trop Dis. 2017 Jan 18;11(1):e0005240. doi: 10.1371/journal.pntd.0005240. eCollection 2017 Jan. PLoS Negl Trop Dis. 2017. PMID: 28099431 Free PMC article.
The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing.
Diaz-Gonzalez R, Kuhlmann FM, Galan-Rodriguez C, Madeira da Silva L, Saldivia M, Karver CE, Rodriguez A, Beverley SM, Navarro M, Pollastri MP. Diaz-Gonzalez R, et al. Among authors: kuhlmann fm. PLoS Negl Trop Dis. 2011 Aug;5(8):e1297. doi: 10.1371/journal.pntd.0001297. Epub 2011 Aug 23. PLoS Negl Trop Dis. 2011. PMID: 21886855 Free PMC article.
Detection of Leishmania RNA virus in Leishmania parasites.
Zangger H, Ronet C, Desponds C, Kuhlmann FM, Robinson J, Hartley MA, Prevel F, Castiglioni P, Pratlong F, Bastien P, Müller N, Parmentier L, Saravia NG, Beverley SM, Fasel N. Zangger H, et al. Among authors: kuhlmann fm. PLoS Negl Trop Dis. 2013;7(1):e2006. doi: 10.1371/journal.pntd.0002006. Epub 2013 Jan 10. PLoS Negl Trop Dis. 2013. PMID: 23326619 Free PMC article.
Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response.
Brettmann EA, Shaik JS, Zangger H, Lye LF, Kuhlmann FM, Akopyants NS, Oschwald DM, Owens KL, Hickerson SM, Ronet C, Fasel N, Beverley SM. Brettmann EA, et al. Among authors: kuhlmann fm. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):11998-12005. doi: 10.1073/pnas.1615085113. Epub 2016 Oct 18. Proc Natl Acad Sci U S A. 2016. PMID: 27790981 Free PMC article.
Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis.
Rossi M, Castiglioni P, Hartley MA, Eren RO, Prével F, Desponds C, Utzschneider DT, Zehn D, Cusi MG, Kuhlmann FM, Beverley SM, Ronet C, Fasel N. Rossi M, et al. Among authors: kuhlmann fm. Proc Natl Acad Sci U S A. 2017 May 9;114(19):4987-4992. doi: 10.1073/pnas.1621447114. Epub 2017 Apr 24. Proc Natl Acad Sci U S A. 2017. PMID: 28439019 Free PMC article.
Degradation of host sphingomyelin is essential for Leishmania virulence.
Zhang O, Wilson MC, Xu W, Hsu FF, Turk J, Kuhlmann FM, Wang Y, Soong L, Key P, Beverley SM, Zhang K. Zhang O, et al. Among authors: kuhlmann fm. PLoS Pathog. 2009 Dec;5(12):e1000692. doi: 10.1371/journal.ppat.1000692. Epub 2009 Dec 11. PLoS Pathog. 2009. PMID: 20011126 Free PMC article.
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