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Page 1
Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity.
Lopchuk JM, Fjelbye K, Kawamata Y, Malins LR, Pan CM, Gianatassio R, Wang J, Prieto L, Bradow J, Brandt TA, Collins MR, Elleraas J, Ewanicki J, Farrell W, Fadeyi OO, Gallego GM, Mousseau JJ, Oliver R, Sach NW, Smith JK, Spangler JE, Zhu H, Zhu J, Baran PS. Lopchuk JM, et al. Among authors: sach nw. J Am Chem Soc. 2017 Mar 1;139(8):3209-3226. doi: 10.1021/jacs.6b13229. Epub 2017 Feb 20. J Am Chem Soc. 2017. PMID: 28140573 Free PMC article.
Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications.
Kawamata Y, Vantourout JC, Hickey DP, Bai P, Chen L, Hou Q, Qiao W, Barman K, Edwards MA, Garrido-Castro AF, deGruyter JN, Nakamura H, Knouse K, Qin C, Clay KJ, Bao D, Li C, Starr JT, Garcia-Irizarry C, Sach N, White HS, Neurock M, Minteer SD, Baran PS. Kawamata Y, et al. J Am Chem Soc. 2019 Apr 17;141(15):6392-6402. doi: 10.1021/jacs.9b01886. Epub 2019 Apr 2. J Am Chem Soc. 2019. PMID: 30905151 Free PMC article.
Organic chemistry. Strain-release amination.
Gianatassio R, Lopchuk JM, Wang J, Pan CM, Malins LR, Prieto L, Brandt TA, Collins MR, Gallego GM, Sach NW, Spangler JE, Zhu H, Zhu J, Baran PS. Gianatassio R, et al. Among authors: sach nw. Science. 2016 Jan 15;351(6270):241-6. doi: 10.1126/science.aad6252. Science. 2016. PMID: 26816372 Free PMC article.
Practical and innate carbon-hydrogen functionalization of heterocycles.
Fujiwara Y, Dixon JA, O'Hara F, Funder ED, Dixon DD, Rodriguez RA, Baxter RD, Herlé B, Sach N, Collins MR, Ishihara Y, Baran PS. Fujiwara Y, et al. Nature. 2012 Dec 6;492(7427):95-9. doi: 10.1038/nature11680. Epub 2012 Nov 28. Nature. 2012. PMID: 23201691 Free PMC article.
High-Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates.
Clement HA, Boghi M, McDonald RM, Bernier L, Coe JW, Farrell W, Helal CJ, Reese MR, Sach NW, Lee JC, Hall DG. Clement HA, et al. Among authors: sach nw. Angew Chem Int Ed Engl. 2019 Dec 16;58(51):18405-18409. doi: 10.1002/anie.201909308. Epub 2019 Oct 31. Angew Chem Int Ed Engl. 2019. PMID: 31591755
Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations.
Johnson TW, Richardson PF, Bailey S, Brooun A, Burke BJ, Collins MR, Cui JJ, Deal JG, Deng YL, Dinh D, Engstrom LD, He M, Hoffman J, Hoffman RL, Huang Q, Kania RS, Kath JC, Lam H, Lam JL, Le PT, Lingardo L, Liu W, McTigue M, Palmer CL, Sach NW, Smeal T, Smith GL, Stewart AE, Timofeevski S, Zhu H, Zhu J, Zou HY, Edwards MP. Johnson TW, et al. Among authors: sach nw. J Med Chem. 2014 Jun 12;57(11):4720-44. doi: 10.1021/jm500261q. Epub 2014 Jun 3. J Med Chem. 2014. PMID: 24819116
Visible-Light-Initiated Manganese Catalysis for C-H Alkylation of Heteroarenes: Applications and Mechanistic Studies.
Nuhant P, Oderinde MS, Genovino J, Juneau A, Gagné Y, Allais C, Chinigo GM, Choi C, Sach NW, Bernier L, Fobian YM, Bundesmann MW, Khunte B, Frenette M, Fadeyi OO. Nuhant P, et al. Among authors: sach nw. Angew Chem Int Ed Engl. 2017 Nov 27;56(48):15309-15313. doi: 10.1002/anie.201707958. Epub 2017 Oct 26. Angew Chem Int Ed Engl. 2017. PMID: 28960645
30 results