Wang L - Search Results

1

Drug Interaction Potential of Osilodrostat (LCI699) Based on Its Effect on the Pharmacokinetics of Probe Drugs of Cytochrome P450 Enzymes in Healthy Adults.

Armani S, Ting L, Sauter N, Darstein C, Tripathi AP, Wang L, Zhu B, Gu H, Chun DY, Einolf HJ, Kulkarni S. Armani S, et al. Among authors: wang l. Clin Drug Investig. 2017 May;37(5):465-472. doi: 10.1007/s40261-017-0497-0. Clin Drug Investig. 2017. PMID: 28155129 Free PMC article. Clinical Trial.

2

Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin.

Gu H, Dutreix C, Rebello S, Ouatas T, Wang L, Chun DY, Einolf HJ, He H. Gu H, et al. Among authors: wang l. Drug Metab Dispos. 2018 Feb;46(2):109-121. doi: 10.1124/dmd.117.078006. Epub 2017 Nov 8. Drug Metab Dispos. 2018. PMID: 29117990

3

Time-dependent inhibition and induction of human cytochrome P4503A4/5 by an oral IAP antagonist, LCL161, in vitro and in vivo in healthy subjects.

Dhuria S, Einolf H, Mangold J, Sen S, Gu H, Wang L, Cameron S. Dhuria S, et al. Among authors: wang l. J Clin Pharmacol. 2013 Jun;53(6):642-53. doi: 10.1002/jcph.79. Epub 2013 Apr 15. J Clin Pharmacol. 2013. PMID: 23585187

4

Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir.

Xia B, Barve A, Heimbach T, Zhang T, Gu H, Wang L, Einolf H, Alexander N, Hanna I, Ke J, Mangold JB, He H, Sunkara G. Xia B, et al. Among authors: wang l. Eur J Pharm Sci. 2014 Oct 15;63:103-12. doi: 10.1016/j.ejps.2014.06.021. Epub 2014 Jul 4. Eur J Pharm Sci. 2014. PMID: 25008118

5

Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline.

Flarakos J, Du Y, Gu H, Wang L, Einolf HJ, Chun DY, Zhu B, Alexander N, Natrillo A, Hanna I, Ting L, Zhou W, Dole K, Sun H, Kovacs SJ, Stein DS, Tanaka SK, Villano S, Mangold JB. Flarakos J, et al. Among authors: wang l. Xenobiotica. 2017 Aug;47(8):682-696. doi: 10.1080/00498254.2016.1213465. Epub 2016 Aug 8. Xenobiotica. 2017. PMID: 27499331 Free article.

6

A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug-Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients.

Einolf HJ, Zhou J, Won C, Wang L, Rebello S. Einolf HJ, et al. Among authors: wang l. Drug Metab Dispos. 2017 Apr;45(4):361-374. doi: 10.1124/dmd.116.073585. Epub 2017 Jan 25. Drug Metab Dispos. 2017. PMID: 28122787 Clinical Trial.

7

Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions.

Einolf HJ, Lin W, Won CS, Wang L, Gu H, Chun DY, He H, Mangold JB. Einolf HJ, et al. Among authors: wang l. Drug Metab Dispos. 2017 Dec;45(12):1304-1316. doi: 10.1124/dmd.117.076851. Epub 2017 Sep 14. Drug Metab Dispos. 2017. PMID: 28912253

8

Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.

Huskey SE, Zhu CQ, Lin MM, Forseth RR, Gu H, Simon O, Eggimann FK, Kittelmann M, Luneau A, Vargas A, Li H, Wang L, Einolf HJ, Zhang J, Favara S, He H, Mangold JB. Huskey SE, et al. Among authors: wang l. Drug Metab Dispos. 2016 May;44(5):653-64. doi: 10.1124/dmd.115.069112. Epub 2016 Feb 26. Drug Metab Dispos. 2016. PMID: 26921386

9

Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism.

Wang-Lakshman L, Miao Z, Wang L, Gu H, Kagan M, Gu J, McNamara E, Walles M, Woessner R, Camenisch G, Einolf HJ, Chen J. Wang-Lakshman L, et al. Among authors: wang l. Drug Metab Dispos. 2021 Jul;49(7):548-562. doi: 10.1124/dmd.120.000349. Epub 2021 May 5. Drug Metab Dispos. 2021. PMID: 33952610 Clinical Trial.

10

Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans.

He H, Tran P, Yin H, Smith H, Batard Y, Wang L, Einolf H, Gu H, Mangold JB, Fischer V, Howard D. He H, et al. Among authors: wang l. Drug Metab Dispos. 2009 Mar;37(3):536-44. doi: 10.1124/dmd.108.023010. Epub 2008 Dec 15. Drug Metab Dispos. 2009. PMID: 19074975

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