Jane D - Search Results

1

The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site.

Safar F, Hurdiss E, Erotocritou M, Greiner T, Lape R, Irvine MW, Fang G, Jane D, Yu R, Dämgen MA, Biggin PC, Sivilotti LG. Safar F, et al. Among authors: jane d. J Biol Chem. 2017 Mar 24;292(12):5031-5042. doi: 10.1074/jbc.M116.767616. Epub 2017 Feb 7. J Biol Chem. 2017. PMID: 28174298 Free PMC article.

2

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors.

Chopra DA, Sapkota K, Irvine MW, Fang G, Jane DE, Monaghan DT, Dravid SM. Chopra DA, et al. Sci Rep. 2017 Jul 31;7(1):6933. doi: 10.1038/s41598-017-07292-8. Sci Rep. 2017. PMID: 28761055 Free PMC article.

3

Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors.

Irvine MW, Costa BM, Dlaboga D, Culley GR, Hulse R, Scholefield CL, Atlason P, Fang G, Eaves R, Morley R, Mayo-Martin MB, Amici M, Bortolotto ZA, Donaldson L, Collingridge GL, Molnár E, Monaghan DT, Jane DE. Irvine MW, et al. Among authors: jane de. J Med Chem. 2012 Jan 12;55(1):327-41. doi: 10.1021/jm201230z. Epub 2011 Dec 14. J Med Chem. 2012. PMID: 22111545 Free PMC article.

4

Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action.

Burnell ES, Irvine M, Fang G, Sapkota K, Jane DE, Monaghan DT. Burnell ES, et al. J Med Chem. 2019 Jan 10;62(1):3-23. doi: 10.1021/acs.jmedchem.7b01640. Epub 2018 Mar 5. J Med Chem. 2019. PMID: 29446949 Free PMC article. Review.

5

Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid.

Irvine MW, Fang G, Sapkota K, Burnell ES, Volianskis A, Costa BM, Culley G, Collingridge GL, Monaghan DT, Jane DE. Irvine MW, et al. Eur J Med Chem. 2019 Feb 15;164:471-498. doi: 10.1016/j.ejmech.2018.12.054. Epub 2018 Dec 28. Eur J Med Chem. 2019. PMID: 30622023 Free PMC article. Review.

6

Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives.

Sapkota K, Irvine MW, Fang G, Burnell ES, Bannister N, Volianskis A, Culley GR, Dravid SM, Collingridge GL, Jane DE, Monaghan DT. Sapkota K, et al. Neuropharmacology. 2017 Oct;125:64-79. doi: 10.1016/j.neuropharm.2017.07.007. Epub 2017 Jul 11. Neuropharmacology. 2017. PMID: 28709671 Free PMC article.

7

Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792.

Sapkota K, Burnell ES, Irvine MW, Fang G, Gawande DY, Dravid SM, Jane DE, Monaghan DT. Sapkota K, et al. Among authors: jane de. Neuropharmacology. 2021 Dec 15;201:108818. doi: 10.1016/j.neuropharm.2021.108818. Epub 2021 Oct 2. Neuropharmacology. 2021. PMID: 34610288

8

A novel family of negative and positive allosteric modulators of NMDA receptors.

Costa BM, Irvine MW, Fang G, Eaves RJ, Mayo-Martin MB, Skifter DA, Jane DE, Monaghan DT. Costa BM, et al. J Pharmacol Exp Ther. 2010 Dec;335(3):614-21. doi: 10.1124/jpet.110.174144. Epub 2010 Sep 21. J Pharmacol Exp Ther. 2010. PMID: 20858708 Free PMC article.

9

Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors.

Irvine MW, Costa BM, Volianskis A, Fang G, Ceolin L, Collingridge GL, Monaghan DT, Jane DE. Irvine MW, et al. Neurochem Int. 2012 Sep;61(4):593-600. doi: 10.1016/j.neuint.2011.12.020. Epub 2012 Jan 13. Neurochem Int. 2012. PMID: 22265875 Free PMC article.

10

Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators.

Monaghan DT, Irvine MW, Costa BM, Fang G, Jane DE. Monaghan DT, et al. Neurochem Int. 2012 Sep;61(4):581-92. doi: 10.1016/j.neuint.2012.01.004. Epub 2012 Jan 17. Neurochem Int. 2012. PMID: 22269804 Free PMC article. Review.

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