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One reporter for in-cell activity profiling of majority of protein kinase oncogenes.
Gudernova I, Foldynova-Trantirkova S, Ghannamova BE, Fafilek B, Varecha M, Balek L, Hruba E, Jonatova L, Jelinkova I, Kunova Bosakova M, Trantirek L, Mayer J, Krejci P. Gudernova I, et al. Among authors: jonatova l. Elife. 2017 Feb 15;6:e21536. doi: 10.7554/eLife.21536. Elife. 2017. PMID: 28199182 Free PMC article.
The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases.
Fafilek B, Balek L, Bosakova MK, Varecha M, Nita A, Gregor T, Gudernova I, Krenova J, Ghosh S, Piskacek M, Jonatova L, Cernohorsky NH, Zieba JT, Kostas M, Haugsten EM, Wesche J, Erneux C, Trantirek L, Krakow D, Krejci P. Fafilek B, et al. Among authors: jonatova l. Sci Signal. 2018 Sep 18;11(548):eaap8608. doi: 10.1126/scisignal.aap8608. Sci Signal. 2018. PMID: 30228226