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Gene transfer as a strategy to achieve permanent cardioprotection I: rAAV-mediated gene therapy with inducible nitric oxide synthase limits infarct size 1 year later without adverse functional consequences.
Li Q, Guo Y, Wu WJ, Ou Q, Zhu X, Tan W, Yuan F, Chen N, Dawn B, Luo L, O'Brien E, Bolli R. Li Q, et al. Basic Res Cardiol. 2011 Nov;106(6):1355-66. doi: 10.1007/s00395-011-0207-7. Epub 2011 Jul 21. Basic Res Cardiol. 2011. PMID: 21779912 Free PMC article.
Genetic background, gender, age, body temperature, and arterial blood pH have a major impact on myocardial infarct size in the mouse and need to be carefully measured and/or taken into account: results of a comprehensive analysis of determinants of infarct size in 1,074 mice.
Guo Y, Flaherty MP, Wu WJ, Tan W, Zhu X, Li Q, Bolli R. Guo Y, et al. Among authors: li q. Basic Res Cardiol. 2012 Sep;107(5):288. doi: 10.1007/s00395-012-0288-y. Epub 2012 Aug 3. Basic Res Cardiol. 2012. PMID: 22864681 Free PMC article.
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