Waxman SG - Search Results

1

Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial.

Zakrzewska JM, Palmer J, Morisset V, Giblin GM, Obermann M, Ettlin DA, Cruccu G, Bendtsen L, Estacion M, Derjean D, Waxman SG, Layton G, Gunn K, Tate S; study investigators. Zakrzewska JM, et al. Among authors: waxman sg. Lancet Neurol. 2017 Apr;16(4):291-300. doi: 10.1016/S1474-4422(17)30005-4. Epub 2017 Feb 17. Lancet Neurol. 2017. PMID: 28216232 Free article. Clinical Trial.

2

Abnormal expression of SNS/PN3 sodium channel in cerebellar Purkinje cells following loss of myelin in the taiep rat.

Black JA, Fjell J, Dib-Hajj S, Duncan ID, O'Connor LT, Fried K, Gladwell Z, Tate S, Waxman SG. Black JA, et al. Among authors: waxman sg. Neuroreport. 1999 Apr 6;10(5):913-8. doi: 10.1097/00001756-199904060-00004. Neuroreport. 1999. PMID: 10321459

3

Nav1.9, G-proteins, and nociceptors.

Waxman SG, Estacion M. Waxman SG, et al. J Physiol. 2008 Feb 15;586(4):917-8. doi: 10.1113/jphysiol.2007.149922. J Physiol. 2008. PMID: 18287383 Free PMC article. No abstract available.

4

Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable.

Dib-Hajj SD, Estacion M, Jarecki BW, Tyrrell L, Fischer TZ, Lawden M, Cummins TR, Waxman SG. Dib-Hajj SD, et al. Among authors: waxman sg. Mol Pain. 2008 Sep 19;4:37. doi: 10.1186/1744-8069-4-37. Mol Pain. 2008. PMID: 18803825 Free PMC article.

5

NaV1.7 gain-of-function mutations as a continuum: A1632E displays physiological changes associated with erythromelalgia and paroxysmal extreme pain disorder mutations and produces symptoms of both disorders.

Estacion M, Dib-Hajj SD, Benke PJ, Te Morsche RH, Eastman EM, Macala LJ, Drenth JP, Waxman SG. Estacion M, et al. Among authors: waxman sg. J Neurosci. 2008 Oct 22;28(43):11079-88. doi: 10.1523/JNEUROSCI.3443-08.2008. J Neurosci. 2008. PMID: 18945915 Free PMC article.

6

A novel Nav1.7 mutation producing carbamazepine-responsive erythromelalgia.

Fischer TZ, Gilmore ES, Estacion M, Eastman E, Taylor S, Melanson M, Dib-Hajj SD, Waxman SG. Fischer TZ, et al. Among authors: waxman sg. Ann Neurol. 2009 Jun;65(6):733-41. doi: 10.1002/ana.21678. Ann Neurol. 2009. PMID: 19557861 Free PMC article.

7

A sodium channel gene SCN9A polymorphism that increases nociceptor excitability.

Estacion M, Harty TP, Choi JS, Tyrrell L, Dib-Hajj SD, Waxman SG. Estacion M, et al. Among authors: waxman sg. Ann Neurol. 2009 Dec;66(6):862-6. doi: 10.1002/ana.21895. Ann Neurol. 2009. PMID: 20033988

8

Can robots patch-clamp as well as humans? Characterization of a novel sodium channel mutation.

Estacion M, Choi JS, Eastman EM, Lin Z, Li Y, Tyrrell L, Yang Y, Dib-Hajj SD, Waxman SG. Estacion M, et al. Among authors: waxman sg. J Physiol. 2010 Jun 1;588(Pt 11):1915-27. doi: 10.1113/jphysiol.2009.186114. Epub 2010 Feb 1. J Physiol. 2010. PMID: 20123784 Free PMC article.

9

A sodium channel mutation linked to epilepsy increases ramp and persistent current of Nav1.3 and induces hyperexcitability in hippocampal neurons.

Estacion M, Gasser A, Dib-Hajj SD, Waxman SG. Estacion M, et al. Among authors: waxman sg. Exp Neurol. 2010 Aug;224(2):362-8. doi: 10.1016/j.expneurol.2010.04.012. Epub 2010 Apr 24. Exp Neurol. 2010. PMID: 20420834

10

Effects of ranolazine on wild-type and mutant hNav1.7 channels and on DRG neuron excitability.

Estacion M, Waxman SG, Dib-Hajj SD. Estacion M, et al. Among authors: waxman sg. Mol Pain. 2010 Jun 8;6:35. doi: 10.1186/1744-8069-6-35. Mol Pain. 2010. PMID: 20529343 Free PMC article.

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