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7-hydroxyfrullanolide, a sesquiterpene lactone, inhibits pro-inflammatory cytokine production from immune cells and is orally efficacious in animal models of inflammation.
Fonseca LC, Dadarkar SS, Lobo AS, Suthar AC, Chauhan VS, Chandrababu S, Sharma SD, Dagia NM, Padigaru M. Fonseca LC, et al. Among authors: dadarkar ss. Eur J Pharmacol. 2010 Oct 10;644(1-3):220-9. doi: 10.1016/j.ejphar.2010.06.052. Epub 2010 Jul 13. Eur J Pharmacol. 2010. PMID: 20621086
A preferential p110alpha/gamma PI3K inhibitor attenuates experimental inflammation by suppressing the production of proinflammatory mediators in a NF-kappaB-dependent manner.
Dagia NM, Agarwal G, Kamath DV, Chetrapal-Kunwar A, Gupte RD, Jadhav MG, Dadarkar SS, Trivedi J, Kulkarni-Almeida AA, Kharas F, Fonseca LC, Kumar S, Bhonde MR. Dagia NM, et al. Among authors: dadarkar ss. Am J Physiol Cell Physiol. 2010 Apr;298(4):C929-41. doi: 10.1152/ajpcell.00461.2009. Epub 2010 Jan 20. Am J Physiol Cell Physiol. 2010. PMID: 20089935 Free article.
Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors.
Deore V, Yewalkar N, Bhatia D, Desai N, Gupte RD, Dadarkar SS, Jadhav MG, Tannu AA, Bhatt P, Nemmani KV, Vishwakarma RA, Sharma S, Roychowdhury A, Dagia NM, Bhonde MR, Kumar S. Deore V, et al. Among authors: dadarkar ss. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2949-52. doi: 10.1016/j.bmcl.2009.04.055. Epub 2009 Apr 18. Bioorg Med Chem Lett. 2009. PMID: 19409777
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