Haouz A - Search Results

1

Bulgecin A: The Key to a Broad-Spectrum Inhibitor That Targets Lytic Transglycosylases.

Williams AH, Wheeler R, Thiriau C, Haouz A, Taha MK, Boneca IG. Williams AH, et al. Among authors: haouz a. Antibiotics (Basel). 2017 Feb 22;6(1):8. doi: 10.3390/antibiotics6010008. Antibiotics (Basel). 2017. PMID: 28241458 Free PMC article.

2

DNA-binding mechanism and evolution of replication protein A.

Madru C, Martínez-Carranza M, Laurent S, Alberti AC, Chevreuil M, Raynal B, Haouz A, Le Meur RA, Delarue M, Henneke G, Flament D, Krupovic M, Legrand P, Sauguet L. Madru C, et al. Among authors: haouz a. Nat Commun. 2023 Apr 22;14(1):2326. doi: 10.1038/s41467-023-38048-w. Nat Commun. 2023. PMID: 37087464 Free PMC article.

3

Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.

Williams AH, Veyrier FJ, Bonis M, Michaud Y, Raynal B, Taha MK, White SW, Haouz A, Boneca IG. Williams AH, et al. Among authors: haouz a. Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2631-9. doi: 10.1107/S1399004714016770. Epub 2014 Sep 27. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 25286847 Free PMC article.

4

A step-by-step in crystallo guide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.

Williams AH, Wheeler R, Rateau L, Malosse C, Chamot-Rooke J, Haouz A, Taha MK, Boneca IG. Williams AH, et al. Among authors: haouz a. J Biol Chem. 2018 Apr 20;293(16):6000-6010. doi: 10.1074/jbc.RA117.001095. Epub 2018 Feb 26. J Biol Chem. 2018. PMID: 29483188 Free PMC article.

5

Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis.

Williams AH, Wheeler R, Deghmane AE, Santecchia I, Schaub RE, Hicham S, Moya Nilges M, Malosse C, Chamot-Rooke J, Haouz A, Dillard JP, Robins WP, Taha MK, Gomperts Boneca I. Williams AH, et al. Among authors: haouz a. Elife. 2020 Feb 5;9:e51247. doi: 10.7554/eLife.51247. Elife. 2020. PMID: 32022687 Free PMC article.

6

High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur.

Weber P, Pissis C, Navaza R, Mechaly AE, Saul F, Alzari PM, Haouz A. Weber P, et al. Among authors: haouz a. Molecules. 2019 Dec 5;24(24):4451. doi: 10.3390/molecules24244451. Molecules. 2019. PMID: 31817305 Free PMC article. Review.

7

Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance.

Mechaly AE, Haouz A, Sassoon N, Buschiazzo A, Betton JM, Alzari PM. Mechaly AE, et al. Among authors: haouz a. J Struct Biol. 2018 Nov;204(2):165-171. doi: 10.1016/j.jsb.2018.08.001. Epub 2018 Aug 4. J Struct Biol. 2018. PMID: 30086390

8

Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.

Walter P, Mechaly A, Bous J, Haouz A, England P, Lai-Kee-Him J, Ancelin A, Hoos S, Baron B, Trapani S, Bron P, Labesse G, Munier-Lehmann H. Walter P, et al. Among authors: haouz a. FEBS J. 2022 Aug;289(16):4869-4887. doi: 10.1111/febs.16393. Epub 2022 Mar 9. FEBS J. 2022. PMID: 35152545 Free article.

9

Molecular basis of vancomycin dependence in VanA-type Staphylococcus aureus VRSA-9.

Meziane-Cherif D, Saul FA, Moubareck C, Weber P, Haouz A, Courvalin P, Périchon B. Meziane-Cherif D, et al. Among authors: haouz a. J Bacteriol. 2010 Oct;192(20):5465-71. doi: 10.1128/JB.00613-10. Epub 2010 Aug 20. J Bacteriol. 2010. PMID: 20729361 Free PMC article.

10

First-in-class allosteric inhibitors of bacterial IMPDHs.

Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugué L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H. Alexandre T, et al. Among authors: haouz a. Eur J Med Chem. 2019 Apr 1;167:124-132. doi: 10.1016/j.ejmech.2019.01.064. Epub 2019 Feb 2. Eur J Med Chem. 2019. PMID: 30769241 Free article.

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