Zhang Q - Search Results

1

Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance.

Wang L, Zhang Q, Zhu G, Zhang Z, Zhi Y, Zhang L, Mao T, Zhou X, Chen Y, Lu T, Tang W. Wang L, et al. Among authors: zhang l, zhang q, zhang z. Eur J Med Chem. 2017 Apr 21;130:86-106. doi: 10.1016/j.ejmech.2017.02.041. Epub 2017 Feb 21. Eur J Med Chem. 2017. PMID: 28242553

2

Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance.

Wang L, Zhu G, Zhang Q, Duan C, Zhang Y, Zhang Z, Zhou Y, Lu T, Tang W. Wang L, et al. Among authors: zhang q, zhang z, zhang y. Org Biomol Chem. 2017 Apr 18;15(16):3455-3465. doi: 10.1039/c7ob00518k. Org Biomol Chem. 2017. PMID: 28368067

3

Potent Pan-Raf and Receptor Tyrosine Kinase Inhibitors Based on a Cyclopropyl Formamide Fragment Overcome Resistance.

Zhang Y, Wang L, Zhang Q, Zhu G, Zhang Z, Zhou X, Chen Y, Lu T, Tang W. Zhang Y, et al. Among authors: zhang q, zhang z. J Chem Inf Model. 2017 Jun 26;57(6):1439-1452. doi: 10.1021/acs.jcim.6b00795. Epub 2017 May 19. J Chem Inf Model. 2017. PMID: 28485964

4

Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance.

Wang L, Zhang Y, Zhang Q, Zhu G, Zhang Z, Duan C, Lu T, Tang W. Wang L, et al. Among authors: zhang q, zhang z, zhang y. Eur J Med Chem. 2019 Feb 1;163:243-255. doi: 10.1016/j.ejmech.2018.11.033. Epub 2018 Nov 16. Eur J Med Chem. 2019. PMID: 30529543

5

Synthesis and biological evaluation of diaryl urea derivatives as FLT3 inhibitors.

Zhang Q, Zhao K, Zhang L, Jiao X, Zhang Y, Tang C. Zhang Q, et al. Among authors: zhang l, zhang y. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127525. doi: 10.1016/j.bmcl.2020.127525. Epub 2020 Sep 6. Bioorg Med Chem Lett. 2020. PMID: 32898697

6

Pyrazolo[1,5-a]pyrimidine based Trk inhibitors: Design, synthesis, biological activity evaluation.

Zhang Y, Liu Y, Zhou Y, Zhang Q, Han T, Tang C, Fan W. Zhang Y, et al. Among authors: zhang q. Bioorg Med Chem Lett. 2021 Jan 1;31:127712. doi: 10.1016/j.bmcl.2020.127712. Epub 2020 Nov 25. Bioorg Med Chem Lett. 2021. PMID: 33246108

7

Synthesis and biological evaluation of new series of quinazoline derivatives as EGFR/HER2 dual-target inhibitors.

Jiao X, Zhang Q, Zhang Y, Shao J, Ding L, Tang C, Feng B. Jiao X, et al. Among authors: zhang q, zhang y. Bioorg Med Chem Lett. 2022 Jul 1;67:128703. doi: 10.1016/j.bmcl.2022.128703. Epub 2022 Mar 29. Bioorg Med Chem Lett. 2022. PMID: 35364239

8

A 4D tensor-enhanced multi-dimensional convolutional neural network for accurate prediction of protein-ligand binding affinity.

Huang D, Wang Y, Sun Y, Ji W, Zhang Q, Jiang Y, Qiu H, Liu H, Lu T, Wei X, Chen Y, Zhang Y. Huang D, et al. Among authors: zhang q, zhang y. Mol Divers. 2024 Dec 23. doi: 10.1007/s11030-024-11044-y. Online ahead of print. Mol Divers. 2024. PMID: 39714563

9

Synthesis and biological evaluation of novel 5,6-dihydrobenzo[h]quinazoline derivatives as FLT3 inhibitors.

Ding L, Zhang Q, Zhao K, Jiao X, Zhou Y, Fan W, Tang C. Ding L, et al. Among authors: zhang q. Chem Biol Drug Des. 2022 Apr;99(4):527-534. doi: 10.1111/cbdd.13992. Epub 2021 Dec 16. Chem Biol Drug Des. 2022. PMID: 34877799

10

Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement.

Moss N, Xiong Z, Burke M, Cogan D, Gao DA, Haverty K, Heim-Riether A, Hickey ER, Nagaraja R, Netherton M, O'Shea K, Ramsden P, Schwartz R, Shih DT, Ward Y, Young E, Zhang Q. Moss N, et al. Among authors: zhang q. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7189-93. doi: 10.1016/j.bmcl.2012.09.054. Epub 2012 Oct 2. Bioorg Med Chem Lett. 2012. PMID: 23084902

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