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Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.
Kilford PJ, Chen KF, Crewe K, Gardner I, Hatley O, Ke AB, Neuhoff S, Zhang M, Rowland Yeo K. Kilford PJ, et al. Among authors: gardner i. CPT Pharmacometrics Syst Pharmacol. 2022 Jul;11(7):822-832. doi: 10.1002/psp4.12794. Epub 2022 Apr 28. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35445542 Free PMC article.
Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework.
Zhang M, Fisher C, Gardner I, Pan X, Kilford P, Bois FY, Jamei M. Zhang M, et al. Among authors: gardner i. Drug Metab Dispos. 2022 Jul;50(7):957-967. doi: 10.1124/dmd.121.000818. Epub 2022 May 3. Drug Metab Dispos. 2022. PMID: 35504655
515 results