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Page 1
L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH.
Intlekofer AM, Wang B, Liu H, Shah H, Carmona-Fontaine C, Rustenburg AS, Salah S, Gunner MR, Chodera JD, Cross JR, Thompson CB. Intlekofer AM, et al. Among authors: cross jr. Nat Chem Biol. 2017 May;13(5):494-500. doi: 10.1038/nchembio.2307. Epub 2017 Mar 6. Nat Chem Biol. 2017. PMID: 28263965 Free PMC article.
ATP-citrate lyase links cellular metabolism to histone acetylation.
Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB. Wellen KE, et al. Among authors: cross jr. Science. 2009 May 22;324(5930):1076-80. doi: 10.1126/science.1164097. Science. 2009. PMID: 19461003 Free PMC article.
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.
Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB. Ward PS, et al. Among authors: cross jr. Cancer Cell. 2010 Mar 16;17(3):225-34. doi: 10.1016/j.ccr.2010.01.020. Epub 2010 Feb 18. Cancer Cell. 2010. PMID: 20171147 Free PMC article.
Induction of sarcomas by mutant IDH2.
Lu C, Venneti S, Akalin A, Fang F, Ward PS, Dematteo RG, Intlekofer AM, Chen C, Ye J, Hameed M, Nafa K, Agaram NP, Cross JR, Khanin R, Mason CE, Healey JH, Lowe SW, Schwartz GK, Melnick A, Thompson CB. Lu C, et al. Among authors: cross jr. Genes Dev. 2013 Sep 15;27(18):1986-98. doi: 10.1101/gad.226753.113. Genes Dev. 2013. PMID: 24065766 Free PMC article.
PTEN is a protein tyrosine phosphatase for IRS1.
Shi Y, Wang J, Chandarlapaty S, Cross J, Thompson C, Rosen N, Jiang X. Shi Y, et al. Nat Struct Mol Biol. 2014 Jun;21(6):522-7. doi: 10.1038/nsmb.2828. Epub 2014 May 11. Nat Struct Mol Biol. 2014. PMID: 24814346 Free PMC article.
210 results