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Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration.
Irwin DC, Baek JH, Hassell K, Nuss R, Eigenberger P, Lisk C, Loomis Z, Maltzahn J, Stenmark KR, Nozik-Grayck E, Buehler PW. Irwin DC, et al. Free Radic Biol Med. 2015 May;82:50-62. doi: 10.1016/j.freeradbiomed.2015.01.012. Epub 2015 Feb 2. Free Radic Biol Med. 2015. PMID: 25656991 Free PMC article.
An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease.
Redinus K, Baek JH, Yalamanoglu A, Shin HKH, Moldova R, Harral JW, Swindle D, Pak D, Ferguson SK, Nuss R, Hassell K, Nozik-Grayck E, Palmer AF, Fini MA, Karoor V, Stenmark KR, Buehler PW, Irwin DC. Redinus K, et al. JCI Insight. 2019 Aug 8;4(15):e127860. doi: 10.1172/jci.insight.127860. eCollection 2019 Aug 8. JCI Insight. 2019. PMID: 31391342 Free PMC article.
93 results