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Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation.
Ando K, Tsushima H, Matsuo E, Horio K, Tominaga-Sato S, Imanishi D, Imaizumi Y, Iwanaga M, Itonaga H, Yoshida S, Hata T, Moriuchi R, Kiyoi H, Nimer S, Mano H, Naoe T, Tomonaga M, Miyazaki Y. Ando K, et al. J Biol Chem. 2013 Mar 29;288(13):9457-67. doi: 10.1074/jbc.M112.415703. Epub 2013 Feb 7. J Biol Chem. 2013. PMID: 23393136 Free PMC article.
Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal.
Zhao X, Chen A, Yan X, Zhang Y, He F, Hayashi Y, Dong Y, Rao Y, Li B, Conway RM, Maiques-Diaz A, Elf SE, Huang N, Zuber J, Xiao Z, Tse W, Tenen DG, Wang Q, Chen W, Mulloy JC, Nimer SD, Huang G. Zhao X, et al. Among authors: nimer sd. Blood. 2014 Mar 13;123(11):1729-38. doi: 10.1182/blood-2013-03-489575. Epub 2014 Jan 21. Blood. 2014. PMID: 24449215 Free PMC article.
Integrative genetic analysis of mouse and human AML identifies cooperating disease alleles.
Hatlen MA, Arora K, Vacic V, Grabowska EA, Liao W, Riley-Gillis B, Oschwald DM, Wang L, Joergens JE, Shih AH, Rapaport F, Gu S, Voza F, Asai T, Neel BG, Kharas MG, Gonen M, Levine RL, Nimer SD. Hatlen MA, et al. Among authors: nimer sd. J Exp Med. 2016 Jan 11;213(1):25-34. doi: 10.1084/jem.20150524. Epub 2015 Dec 14. J Exp Med. 2016. PMID: 26666262 Free PMC article.
Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer.
Ando M, Kawazu M, Ueno T, Koinuma D, Ando K, Koya J, Kataoka K, Yasuda T, Yamaguchi H, Fukumura K, Yamato A, Soda M, Sai E, Yamashita Y, Asakage T, Miyazaki Y, Kurokawa M, Miyazono K, Nimer SD, Yamasoba T, Mano H. Ando M, et al. Among authors: nimer sd. Cancer Res. 2016 Apr 1;76(7):1814-24. doi: 10.1158/0008-5472.CAN-14-3816. Epub 2016 Feb 26. Cancer Res. 2016. PMID: 26921333
Loss of p300 accelerates MDS-associated leukemogenesis.
Cheng G, Liu F, Asai T, Lai F, Man N, Xu H, Chen S, Greenblatt S, Hamard PJ, Ando K, Chen X, Wang L, Martinez C, Tadi M, Wang L, Xu M, Yang FC, Shiekhattar R, Nimer SD. Cheng G, et al. Among authors: nimer sd. Leukemia. 2017 Jun;31(6):1382-1390. doi: 10.1038/leu.2016.347. Epub 2016 Nov 24. Leukemia. 2017. PMID: 27881875 Free PMC article.
284 results