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Rationale and Design of a Phase 1 Clinical Trial to Evaluate HSV G207 Alone or with a Single Radiation Dose in Children with Progressive or Recurrent Malignant Supratentorial Brain Tumors.
Waters AM, Johnston JM, Reddy AT, Fiveash J, Madan-Swain A, Kachurak K, Bag AK, Gillespie GY, Markert JM, Friedman GK. Waters AM, et al. Among authors: johnston jm. Hum Gene Ther Clin Dev. 2017 Mar;28(1):7-16. doi: 10.1089/humc.2017.002. Hum Gene Ther Clin Dev. 2017. PMID: 28319448 Free PMC article. Clinical Trial.
Stereotactic Placement of Intratumoral Catheters for Continuous Infusion Delivery of Herpes Simplex Virus -1 G207 in Pediatric Malignant Supratentorial Brain Tumors.
Bernstock JD, Wright Z, Bag AK, Gessler F, Gillespie GY, Markert JM, Friedman GK, Johnston JM. Bernstock JD, et al. Among authors: johnston jm. World Neurosurg. 2019 Feb;122:e1592-e1598. doi: 10.1016/j.wneu.2018.11.122. Epub 2018 Nov 24. World Neurosurg. 2019. PMID: 30481622 Free PMC article.
A novel in situ multiplex immunofluorescence panel for the assessment of tumor immunopathology and response to virotherapy in pediatric glioblastoma reveals a role for checkpoint protein inhibition.
Bernstock JD, Vicario N, Rong L, Valdes PA, Choi BD, Chen JA, DiToro D, Osorio DS, Kachurak K, Gessler F, Johnston JM Jr, Atkinson TP, Whitley RJ, Bag AK, Gillespie GY, Markert JM, Maric D, Friedman GK. Bernstock JD, et al. Among authors: johnston jm jr. Oncoimmunology. 2019 Oct 21;8(12):e1678921. doi: 10.1080/2162402X.2019.1678921. eCollection 2019. Oncoimmunology. 2019. PMID: 31741780 Free PMC article.
Treatment of pediatric high-grade central nervous system tumors with high-dose methotrexate in combination with multiagent chemotherapy: A single-institution experience.
Bernstock JD, Alva E, Cohen JL, Lobbous M, Chagoya G, Elsayed GA, Orr BA, Rozzelle C, Rocque B, Blount J, Johnston JM, Li R, Fiveash JB, Dhall G, Reddy AT, Friedman GK. Bernstock JD, et al. Among authors: johnston jm. Pediatr Blood Cancer. 2020 Mar;67(3):e28119. doi: 10.1002/pbc.28119. Epub 2019 Dec 18. Pediatr Blood Cancer. 2020. PMID: 31850678 Clinical Trial.
Design and Rationale for First-in-Human Phase 1 Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar Brain Tumors.
Bernstock JD, Bag AK, Fiveash J, Kachurak K, Elsayed G, Chagoya G, Gessler F, Valdes PA, Madan-Swain A, Whitley R, Markert JM, Gillespie GY, Johnston JM, Friedman GK. Bernstock JD, et al. Among authors: johnston jm. Hum Gene Ther. 2020 Oct;31(19-20):1132-1139. doi: 10.1089/hum.2020.101. Epub 2020 Aug 17. Hum Gene Ther. 2020. PMID: 32657154 Free PMC article.
Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas.
Friedman GK, Johnston JM, Bag AK, Bernstock JD, Li R, Aban I, Kachurak K, Nan L, Kang KD, Totsch S, Schlappi C, Martin AM, Pastakia D, McNall-Knapp R, Farouk Sait S, Khakoo Y, Karajannis MA, Woodling K, Palmer JD, Osorio DS, Leonard J, Abdelbaki MS, Madan-Swain A, Atkinson TP, Whitley RJ, Fiveash JB, Markert JM, Gillespie GY. Friedman GK, et al. Among authors: johnston jm. N Engl J Med. 2021 Apr 29;384(17):1613-1622. doi: 10.1056/NEJMoa2024947. Epub 2021 Apr 10. N Engl J Med. 2021. PMID: 33838625 Free PMC article.
Clinical advances in oncolytic virotherapy for pediatric brain tumors.
Ghajar-Rahimi G, Kang KD, Totsch SK, Gary S, Rocco A, Blitz S, Kachurak K, Chambers MR, Li R, Beierle EA, Bag A, Johnston JM, Markert JM, Bernstock JD, Friedman GK. Ghajar-Rahimi G, et al. Among authors: johnston jm. Pharmacol Ther. 2022 Nov;239:108193. doi: 10.1016/j.pharmthera.2022.108193. Epub 2022 Apr 26. Pharmacol Ther. 2022. PMID: 35487285 Free PMC article. Review.
The safety and accuracy of intratumoral catheter placement to infuse viral immunotherapies in children with malignant brain tumors: a multi-institutional study.
Barkley A, Butler E, Park C, Friedman A, Landi D, Ashley DM, Bigner D, Bernstock JD, Friedman GK, Johnston JM, Thompson EM. Barkley A, et al. Among authors: johnston jm. J Neurosurg Pediatr. 2024 Jan 12;33(4):359-366. doi: 10.3171/2023.12.PEDS23404. Print 2024 Apr 1. J Neurosurg Pediatr. 2024. PMID: 38215438 Free PMC article.
Identification of targets for rational pharmacological therapy in childhood craniopharyngioma.
Gump JM, Donson AM, Birks DK, Amani VM, Rao KK, Griesinger AM, Kleinschmidt-DeMasters BK, Johnston JM, Anderson RC, Rosenfeld A, Handler M, Gore L, Foreman N, Hankinson TC. Gump JM, et al. Among authors: johnston jm. Acta Neuropathol Commun. 2015 May 21;3:30. doi: 10.1186/s40478-015-0211-5. Acta Neuropathol Commun. 2015. PMID: 25990246 Free PMC article.
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