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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY. Alsamman S, et al. Among authors: newcomb b. Sci Transl Med. 2020 Aug 19;12(557):eaay8798. doi: 10.1126/scitranslmed.aay8798. Sci Transl Med. 2020. PMID: 32817366 Free PMC article.
Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.
Bai A, Szulc ZM, Bielawski J, Pierce JS, Rembiesa B, Terzieva S, Mao C, Xu R, Wu B, Clarke CJ, Newcomb B, Liu X, Norris J, Hannun YA, Bielawska A. Bai A, et al. Among authors: newcomb b. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44. doi: 10.1016/j.bmc.2014.10.025. Epub 2014 Oct 22. Bioorg Med Chem. 2014. PMID: 25456083 Free PMC article.
Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway.
Perry DM, Newcomb B, Adada M, Wu BX, Roddy P, Kitatani K, Siskind L, Obeid LM, Hannun YA. Perry DM, et al. Among authors: newcomb b. J Biol Chem. 2014 Aug 8;289(32):22401-12. doi: 10.1074/jbc.M114.589648. Epub 2014 Jun 20. J Biol Chem. 2014. PMID: 24951586 Free PMC article.
The plant decapeptide OSIP108 prevents copper-induced apoptosis in yeast and human cells.
Spincemaille P, Chandhok G, Newcomb B, Verbeek J, Vriens K, Zibert A, Schmidt H, Hannun YA, van Pelt J, Cassiman D, Cammue BPA, Thevissen K. Spincemaille P, et al. Among authors: newcomb b. Biochim Biophys Acta. 2014 Jun;1843(6):1207-1215. doi: 10.1016/j.bbamcr.2014.03.004. Epub 2014 Mar 13. Biochim Biophys Acta. 2014. PMID: 24632503 Free PMC article.
34 results