Amano N - Search Results

1

A Selective Bombesin Receptor Subtype 3 Agonist Promotes Weight Loss in Male Diet-Induced-Obese Rats With Circadian Rhythm Change.

Nio Y, Hotta N, Maruyama M, Hamagami K, Nagi T, Funata M, Sakamoto J, Nakakariya M, Amano N, Okawa T, Arikawa Y, Sasaki S, Okuda S, Kasai S, Habata Y, Nagisa Y. Nio Y, et al. Among authors: amano n. Endocrinology. 2017 May 1;158(5):1298-1313. doi: 10.1210/en.2016-1825. Endocrinology. 2017. PMID: 28324017

2

In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes.

Nakakariya M, Ono M, Amano N, Moriwaki T, Maeda K, Sugiyama Y. Nakakariya M, et al. Among authors: amano n. Drug Metab Dispos. 2012 Mar;40(3):602-9. doi: 10.1124/dmd.111.042101. Epub 2011 Dec 21. Drug Metab Dispos. 2012. PMID: 22190695

3

Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors.

Kamata M, Yamashita T, Kina A, Funata M, Mizukami A, Sasaki M, Tani A, Funami M, Amano N, Fukatsu K. Kamata M, et al. Among authors: amano n. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3643-7. doi: 10.1016/j.bmcl.2012.04.047. Epub 2012 Apr 19. Bioorg Med Chem Lett. 2012. PMID: 22560583

4

Discovery of a Novel Series of N-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors.

Sato K, Takahagi H, Yoshikawa T, Morimoto S, Takai T, Hidaka K, Kamaura M, Kubo O, Adachi R, Ishii T, Maki T, Mochida T, Takekawa S, Nakakariya M, Amano N, Kitazaki T. Sato K, et al. Among authors: amano n. J Med Chem. 2015 May 14;58(9):3892-909. doi: 10.1021/acs.jmedchem.5b00178. Epub 2015 Apr 30. J Med Chem. 2015. PMID: 25897973

5

Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities.

Sato K, Takahagi H, Kubo O, Hidaka K, Yoshikawa T, Kamaura M, Nakakariya M, Amano N, Adachi R, Maki T, Take K, Takekawa S, Kitazaki T, Maekawa T. Sato K, et al. Among authors: amano n. Bioorg Med Chem. 2015 Aug 1;23(15):4544-4560. doi: 10.1016/j.bmc.2015.06.003. Epub 2015 Jun 9. Bioorg Med Chem. 2015. PMID: 26100443

6

Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization.

Take K, Mochida T, Maki T, Satomi Y, Hirayama M, Nakakariya M, Amano N, Adachi R, Sato K, Kitazaki T, Takekawa S. Take K, et al. Among authors: amano n. PLoS One. 2016 Mar 3;11(3):e0150976. doi: 10.1371/journal.pone.0150976. eCollection 2016. PLoS One. 2016. PMID: 26938273 Free PMC article.

7

Appropriate risk criteria for OATP inhibition at the drug discovery stage based on the clinical relevancy between OATP inhibitors and drug-induced adverse effect.

Nakakariya M, Goto A, Amano N. Nakakariya M, et al. Among authors: amano n. Drug Metab Pharmacokinet. 2016 Oct;31(5):333-339. doi: 10.1016/j.dmpk.2016.05.003. Epub 2016 May 28. Drug Metab Pharmacokinet. 2016. PMID: 27567380

8

Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of the Glucagon-Like Peptide-1 Receptor Agonist Exenatide to Characterize Its Antiobesity Effects in Diet-Induced Obese Mice.

Iwasaki S, Hamada T, Chisaki I, Andou T, Sano N, Furuta A, Amano N. Iwasaki S, et al. Among authors: amano n. J Pharmacol Exp Ther. 2017 Sep;362(3):441-449. doi: 10.1124/jpet.117.242651. Epub 2017 Jul 11. J Pharmacol Exp Ther. 2017. PMID: 28698254

9

Bombesin receptor subtype-3-expressing neurons regulate energy homeostasis through a novel neuronal pathway in the hypothalamus.

Maruyama M, Hotta N, Nio Y, Hamagami K, Nagi T, Funata M, Sakamoto J, Nakakariya M, Amano N, Nishida M, Okawa T, Arikawa Y, Sasaki S, Kasai S, Nagisa Y, Habata Y, Mori M. Maruyama M, et al. Among authors: amano n. Brain Behav. 2017 Dec 15;8(1):e00881. doi: 10.1002/brb3.881. eCollection 2018 Jan. Brain Behav. 2017. PMID: 29568682 Free PMC article.

10

Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor.

Yukawa T, Nakahata T, Okamoto R, Ishichi Y, Miyamoto Y, Nishimura S, Oikawa T, Kubo K, Adachi R, Satomi Y, Nakakariya M, Amano N, Kamaura M, Matsunaga N. Yukawa T, et al. Among authors: amano n. Bioorg Med Chem. 2020 Apr 1;28(7):115376. doi: 10.1016/j.bmc.2020.115376. Epub 2020 Feb 12. Bioorg Med Chem. 2020. PMID: 32088125

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