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Page 1
Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy.
Reschke CR, Silva LFA, Norwood BA, Senthilkumar K, Morris G, Sanz-Rodriguez A, Conroy RM, Costard L, Neubert V, Bauer S, Farrell MA, O'Brien DF, Delanty N, Schorge S, Pasterkamp RJ, Rosenow F, Henshall DC. Reschke CR, et al. Among authors: pasterkamp rj. Mol Ther Nucleic Acids. 2017 Mar 17;6:45-56. doi: 10.1016/j.omtn.2016.11.002. Epub 2016 Dec 10. Mol Ther Nucleic Acids. 2017. PMID: 28325299 Free PMC article.
MicroRNAs in epilepsy: pathophysiology and clinical utility.
Henshall DC, Hamer HM, Pasterkamp RJ, Goldstein DB, Kjems J, Prehn JHM, Schorge S, Lamottke K, Rosenow F. Henshall DC, et al. Among authors: pasterkamp rj. Lancet Neurol. 2016 Dec;15(13):1368-1376. doi: 10.1016/S1474-4422(16)30246-0. Lancet Neurol. 2016. PMID: 27839653 Review.
Antagonizing Increased miR-135a Levels at the Chronic Stage of Experimental TLE Reduces Spontaneous Recurrent Seizures.
Vangoor VR, Reschke CR, Senthilkumar K, van de Haar LL, de Wit M, Giuliani G, Broekhoven MH, Morris G, Engel T, Brennan GP, Conroy RM, van Rijen PC, Gosselaar PH, Schorge S, Schaapveld RQJ, Henshall DC, De Graan PNE, Pasterkamp RJ. Vangoor VR, et al. Among authors: pasterkamp rj. J Neurosci. 2019 Jun 26;39(26):5064-5079. doi: 10.1523/JNEUROSCI.3014-18.2019. Epub 2019 Apr 23. J Neurosci. 2019. PMID: 31015341 Free PMC article.
Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy.
Schijven D, Stevelink R, McCormack M, van Rheenen W, Luykx JJ, Koeleman BPC, Veldink JH; Project MinE ALS GWAS Consortium; International League Against Epilepsy Consortium on Complex Epilepsies. Schijven D, et al. Neurobiol Aging. 2020 Aug;92:153.e1-153.e5. doi: 10.1016/j.neurobiolaging.2020.04.011. Epub 2020 Apr 18. Neurobiol Aging. 2020. PMID: 32409253 Free PMC article.
A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy.
Venø MT, Reschke CR, Morris G, Connolly NMC, Su J, Yan Y, Engel T, Jimenez-Mateos EM, Harder LM, Pultz D, Haunsberger SJ, Pal A, Heller JP, Campbell A, Langa E, Brennan GP, Conboy K, Richardson A, Norwood BA, Costard LS, Neubert V, Del Gallo F, Salvetti B, Vangoor VR, Sanz-Rodriguez A, Muilu J, Fabene PF, Pasterkamp RJ, Prehn JHM, Schorge S, Andersen JS, Rosenow F, Bauer S, Kjems J, Henshall DC. Venø MT, et al. Among authors: pasterkamp rj. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15977-15988. doi: 10.1073/pnas.1919313117. Epub 2020 Jun 24. Proc Natl Acad Sci U S A. 2020. PMID: 32581127 Free PMC article.
Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy.
Reschke CR, Silva LFA, Vangoor VR, Rosso M, David B, Cavanagh BL, Connolly NMC, Brennan GP, Sanz-Rodriguez A, Mooney C, Batool A, Greene C, Brennan M, Conroy RM, Rüber T, Prehn JHM, Campbell M, Pasterkamp RJ, Henshall DC. Reschke CR, et al. Among authors: pasterkamp rj. Mol Ther. 2021 Jun 2;29(6):2041-2052. doi: 10.1016/j.ymthe.2021.02.021. Epub 2021 Feb 18. Mol Ther. 2021. PMID: 33609732 Free PMC article.
Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology.
Gomes-Duarte A, Venø MT, de Wit M, Senthilkumar K, Broekhoven MH, van den Herik J, Heeres FR, van Rossum D, Rybiczka-Tesulov M, Legnini I, van Rijen PC, van Eijsden P, Gosselaar PH, Rajewsky N, Kjems J, Vangoor VR, Pasterkamp RJ. Gomes-Duarte A, et al. Among authors: pasterkamp rj. Front Mol Neurosci. 2022 Mar 3;15:832133. doi: 10.3389/fnmol.2022.832133. eCollection 2022. Front Mol Neurosci. 2022. PMID: 35310884 Free PMC article.
shRNA-induced saturation of the microRNA pathway in the rat brain.
van Gestel MA, van Erp S, Sanders LE, Brans MA, Luijendijk MC, Merkestein M, Pasterkamp RJ, Adan RA. van Gestel MA, et al. Among authors: pasterkamp rj. Gene Ther. 2014 Feb;21(2):205-11. doi: 10.1038/gt.2013.76. Epub 2014 Jan 2. Gene Ther. 2014. PMID: 24385145
192 results