Morissette P - Search Results

1

Cardiac drug-drug interaction between HCV-NS5B pronucleotide inhibitors and amiodarone is determined by their specific diastereochemistry.

Lagrutta A, Regan CP, Zeng H, Imredy JP, Koeplinger K, Morissette P, Liu L, Wollenberg G, Brynczka C, Lebrón J, DeGeorge J, Sannajust F. Lagrutta A, et al. Among authors: morissette p. Sci Rep. 2017 Mar 22;7:44820. doi: 10.1038/srep44820. Sci Rep. 2017. PMID: 28327633 Free PMC article.

2

Assessment of the clinical cardiac drug-drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys.

Regan CP, Morissette P, Regan HK, Travis JJ, Gerenser P, Wen J, Fitzgerald K, Gruver S, DeGeorge JJ, Sannajust FJ. Regan CP, et al. Among authors: morissette p. Hepatology. 2016 Nov;64(5):1430-1441. doi: 10.1002/hep.28752. Epub 2016 Aug 23. Hepatology. 2016. PMID: 27474787

3

Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay.

Morissette P, Polak S, Chain A, Zhai J, Imredy JP, Wildey MJ, Travis J, Fitzgerald K, Fanelli P, Passini E, Rodriguez B, Sannajust F, Regan C. Morissette P, et al. Toxicol Appl Pharmacol. 2020 Mar 1;390:114883. doi: 10.1016/j.taap.2020.114883. Epub 2020 Jan 23. Toxicol Appl Pharmacol. 2020. PMID: 31981640 Free PMC article.

4

QT interval correction assessment in the anesthetized guinea pig.

Morissette P, Regan HK, Fitzgerald K, Bernasconi S, Gerenser P, Travis J, Fanelli P, Sannajust F, Regan CP. Morissette P, et al. J Pharmacol Toxicol Methods. 2015 Sep-Oct;75:52-61. doi: 10.1016/j.vascn.2015.05.007. Epub 2015 May 19. J Pharmacol Toxicol Methods. 2015. PMID: 26001325

5

[No title available]

[No authors listed] [No authors listed] PMID: 31962998

6

[No title available]

[No authors listed] [No authors listed] PMID: 31963044

7

Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development.

Morissette P, Regan C, Fitzgerald K, Gerenser P, Travis J, Wang S, Fanelli P, Sannajust F. Morissette P, et al. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:171-82. doi: 10.1016/j.vascn.2016.06.003. Epub 2016 Jul 1. J Pharmacol Toxicol Methods. 2016. PMID: 27377419

8

The anesthetized guinea pig: an effective early cardiovascular derisking and lead optimization model.

Morissette P, Nishida M, Trepakova E, Imredy J, Lagrutta A, Chaves A, Hoagland K, Hoe CM, Zrada MM, Travis JJ, Zingaro GJ, Gerenser P, Friedrichs G, Salata JJ. Morissette P, et al. J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):137-49. doi: 10.1016/j.vascn.2013.04.010. Epub 2013 May 4. J Pharmacol Toxicol Methods. 2013. PMID: 23649000

9

Sensitivity of pharmacokinetic-pharmacodynamic analysis for detecting small magnitudes of QTc prolongation in preclinical safety testing.

Gotta V, Cools F, van Ammel K, Gallacher DJ, Visser SA, Sannajust F, Morissette P, Danhof M, van der Graaf PH. Gotta V, et al. Among authors: morissette p. J Pharmacol Toxicol Methods. 2015 Mar-Apr;72:1-10. doi: 10.1016/j.vascn.2014.12.008. Epub 2014 Dec 31. J Pharmacol Toxicol Methods. 2015. PMID: 25556117

10

Drug-induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias.

Passini E, Trovato C, Morissette P, Sannajust F, Bueno-Orovio A, Rodriguez B. Passini E, et al. Among authors: morissette p. Br J Pharmacol. 2019 Oct;176(19):3819-3833. doi: 10.1111/bph.14786. Epub 2019 Sep 4. Br J Pharmacol. 2019. PMID: 31271649 Free PMC article.

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